Upstream Production Engineer I

Posted 27 Feb 2020

Shanghai - all, Shanghai - China

Req Id 201105

Details

A career at our company is an ongoing journey of discovery: our around 56,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others.


 

Position Information

Title

Upstream Production Engineer I

Department

E2E APAC

Report to

Upstream Production Associate Manager

Location

Shanghai

 

Major Responsibility

Mammalian cell production

  • Perform cell banking, production in 200L/2000L single-use bioreactor and clarification in compliance with Good Manufacturing Practice (GMP) regulations
  • Record all process data and information truly and correctly
  • Perform in process control of bioreactor and deliver samples to quality control (QC) department
  • Effective communication on the data and results with line manager and upstream production team
  • Prepare and review tech transfer protocol, batch record and production report
  • Propose solutions to risks or issues in the whole production activities
  • Show logical and cautious thinking in the whole production activities
  • Implement any other work related to production activities

Routine activities

  • Participate in the tech transfer of internal (from process development lab) and external process
  • Involve in the use, record and maintenance of the cell bank according to the responsibility define in SOP
  • Schedule medium and buffer preparation and collaborate with support team
  • Prepare and review standard operation procedure (SOP) and worksheet related to upstream production
  • Participate or lead the qualification (IQ/OQ/PQ/RQ), calibration and maintenance of equipment
  • Check the inventory and place order for reagents, consumables and any other raw materials of upstream production
  • Finish the training of upstream related SOP, equipment and experiment
  • Organize or provide training to the staff from relevant team or department
  • Finish the public or facility related work including checking, cleaning and disinfection
  • Support and participate in the continuous improvement activities

Compliance and Good behavior

  • Make sure all activities are compliant with the policy of the lab, company and regulatory requirements
  • Follow the quality rules defined in quality manual
  • Inform line manager of any problems encountered, carry out the investigations and propose the appropriate solutions in collaboration with the team concerned
  • No fraud, modification, delete of any experiment data and information
  • Ensure and encourage the establishment of adequate solutions to avoid recurrence of production problems
  • Show team spirit, proactive and optimistic characters in work

 

 

Qualification

Education

  • Bachelor’s degree of science or above
  • Major in Biology, Cell Biology, Biochemistry, Chemical Engineering, Biotechnology, Pharmacy, Bioengineering, or equivalent

Work experience

  • Above 2-year experience in mammalian cell culture techniques (process development, pilot scale or production)
  • Experience in GMP facility and good concept of quality
  • Master of theory and practice of biopharmaceutical technique
  • Knowledge of single-use technology (equipment and consumables)

Skills

  • Skilled in using Microsoft Office software
  • Good written and oral communication skills with peers and managers
  • Skilled in English reading and writing
  • Ability of English listening and speaking is a plus

What we offer:  With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!

Curious? Apply and find more information at https://jobs.vibrantm.com

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