Senior Scientist Process and Analytical Development

Posted 11 Aug 2020

St. Louis, Missouri - United States

Req Id 209034


A career with MilliporeSigma is an ongoing journey of discovery: our 57,000 people are shaping how the world lives, works and plays through next generation advancements in healthcare, life science and performance materials. For more than 350 years and across the world we have passionately pursued our curiosity to find novel and vibrant ways of enhancing the lives of others. EMD Performance Materials is a business of Merck KGaA, Darmstadt, Germany.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role:

The ideal candidate will lead a project to accomplish bio-conjugation process chemistry technology transfer and development campaigns designed to deliver robust and cost-effective production processes to GMP manufacturing.


  • Leverage experience in protein biochemistry and/or conjugation chemistry to on-board/develop, optimize, and scale-up bio-conjugation process chemistry unit operations.
  • Effectively work with key stakeholders to technology transfer time-sensitive bio-conjugation production processes to GMP manufacturing.
  • Utilize experience in protein biochemistry for generic analysis and characterization of protein conjugates.
  • Troubleshoot bio-conjugate production process non-conformances and deliver data-driven solutions
  • Exempt role and extended days and/or possible weekend shifts for special projects occur occasionally throughout the year


Physical Attributes:

  • Position requires lifting/pushing/pulling of 50lbs  
  • Utilize all required PPE  
  • Position requires routine use of all quantities of all classes of chemicals
  • Position works with highly potent compounds and respirators may be required  



Who You Are:


Minimum Qualifications:

  • Ph.D. in Biochemistry, Chemistry, Biology or another life science discipline with 3+ years of industrial experience OR Master’s Degree in Biochemistry, Chemistry, Biology or another life science discipline with 5+ years of industrial experience OR Bachelor’s degree with 10+ years of industrial experience
  • 4+ years of experience in high project impact when leading or contributing to multidisciplinary scientific teams
  • 2+ years of experience in protein or other biopolymer purification at both the bench and production scale employing state of the art chromatographic and ultrafiltration unit operations
  • 2+ years of experience in qualitative and quantitative characterization protein and/or bio-conjugate employing current and evolving analytical methods


Preferred Qualifications:

  • Experience in bio-conjugation process chemistry development and optimization, including the use of Design of Experiments, approaches highly preferred
  • Experience with protein purification, or oligo nucleotide purification on preparative scale strongly preferred
  • Strong experience in research and development in either industry or academia is preferred
  • Experience related to chemical and/or enzymatic conjugation of small molecule payloads to biopolymer scaffolds strongly preferred
  • Exemplary communication skills including timely and concise written and oral communications to both external and internal project stakeholders
  • Attention to detail in planning, execution, and documentation of experimental work



What we offer: With us, there are always opportunities to break new ground. We empower you to fulfil your ambitions, and our diverse businesses offer various career moves to seek new horizons. We trust you with responsibility early on and support you to draw your own career map that is responsive to your aspirations and priorities in life. Join us and bring your curiosity to life!

Curious? Apply and find more information at

The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

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