Production Scientist

Posted 01 Jan 2023

Jerusalem, Jerusalem - Israel

Req Id 259843

 

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CONTEXT

The importance of protein biochemistry in the global life science industry has grown significantly in the past 10 years. Production of bioactive and structural proteins for the healthcare industry, academia and applied segments play an increasingly important and impactful role in Merck’s business operations. Strong Biochemical background together with high performance abilities has become a necessity in today's operation of the protein purification department.

 

PURPOSE OF THE ROLE

Proteins biochemist is responsible for proteins purification from natural sources such as plant and mammalian tissues as well as fermentation sources (bacteria and yeast).

The employee operates downstream-process equipment (chromatography columns, Ultra-Filtration, dialysis, etc.)

tests the sample of the in-process and final product (protein content, purity, activity) to ensure quantity and quality and employee analyzes and document the test results. In addition the chemist performs trouble shooting to solve for process difficulties and reviews and corrects all documentation related to the production process.

 

 

KEY TASKS & RESPONSIBILITIES

  • Extraction/purification of proteins from microbial fermentations and other natural sources.
  • Preparation of solutions in large quantities.
  • Operation of industrial chromatography methods (Gel-filtration, Ion-exchange, Affinity) using FPLC.
  • Operation of analytical equipment: SDS-PAGE, spectrophotometer, etc.
  • Performing all activities during the production processes in compliance with health and safety regulations.
  • Carrying out process improvement, scale-up and implementation of new technologies.
  • Writing and reviewing protocols and all necessary documents according to compliance.

 

MAIN INTERFACES

 

INTERNALLY: 

Inventory and logistic control

Fermentation unit

Packaging department

QC/QA

Kits & ready-made department

Maintenance department

 

EXTERNALLY:

  • None

 

QUALIFICATIONS

 

EDUCATION/LANGUAGES

 

  • B.Sc. or M.Sc. in Biochemistry, Biotechnology or Process Engineering.
  • Fluent in English.

PROFESSIONAL SKILLS & EXPERIENCE

  • Experience in laboratory work.
  • Experience with analytical methods (SDS-PAGE, Lowry, Bradford, Biuret, enzymology(.
  • Experience with sterile work – advantage.
  • Experience in purification of proteins – advantage.

 

 

PERSONAL SKILLS & COMPETENCIES

  • Strong knowledge of proteins purification methods – advantage.
  • Teamwork
  • Initiative/self-motivated
  • Drive


What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We celebrate all dimensions of diversity and believe that it drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
 
Apply now and become a part of our diverse team!


Equal Employment Opportunities

The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

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