Principle Scientist, Translational Quantitative Pharmacology

Posted 11 Jul 2023

Bangalore, Karnataka - India

Req Id 265068


Work Your Magic with us!

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.



Your role:

  • To be able to independently develop quantitative mechanism-based PK/PD models that will inform compound progression decisions from lead optimization to clinical proof of concept and beyond for the immunology and oncology pipelines, both for large and small molecule pharmaceuticals.
  • The selected candidate will have responsibilities for performing human PK predictions and quantitative DDI predictions, the design and analysis of pre-clinical PK/PD data to support lead optimization and prioritization, and translational PK/PD analyses to support FIM dose estimates for both small/large molecules and ADCs.
  • The candidate will work to develop models or use commercially available software tools to understand and quantify toxicological signals such as cardiovascular, hepatic, renal, dermal etc to determine the therapeutic index and help guide project decisions
  • To be able to interact with various project team members in a clear and timely manner, understanding the functions of other team members and being able to explain and educate modeling efforts and results to team members from various backgrounds
  • The successful candidate will work in a dynamic team with frequent interactions, both within the team and associated functions, and is responsible for the development and implementation of innovative modeling and simulation platforms/strategy that ensure that the right drug is administered to the right patient at the right dose/regimen.
  • The selected candidate will work in close partnership with Pharmacology, Safety, Clinical Sciences, Biostatics and Regulatory.  As a member of project teams and sub-teams, the candidate will represent QP and present analysis outcomes to cross-functional teams, at department meetings, project review committees and conferences.
  • The candidate will contribute to the preparation and presentation of both internal and external documentation (e.g. Investigator’s Brochure, IND, CTD) and product strategy

Interfaces with other Departments/Functions:

  • Oncology and Immunology Research Units
  • Clinical Pharmacology (CP)
  • Biostatistics
  • Safety sciences (Toxicology)
  • DMPK
  • Epidemiology/Biomarkers
  • Pharmacometrics
  • Bioinformatics
  • Project Teams (CP, Biomarkers and GPT)

External Interfaces:

  • Represent company/ organization in consortia (e.g. IQ working groups) and academic research partnerships.
  • Represent function and department in interactions with contractors
  • Present and publish work in relevant journals and MIDD related conferences.

Who you are:


  • A minimum of 3 years in industry and/or academia in a relevant background
  • A PhD in Pharmacokinetics, Pharmaceutical Sciences, Biomedical/Chemical Engineering, Applied Mathematics, Statistics or a related discipline with a proven track record of applying modeling and simulation approaches to biological problems
  • Fluency in English.


  • In-depth hands-on experience with modeling software (such as; MatLab, R, Phoenix/WinNonlin, NONMEM, Monolix etc)
  • Experience with DDI predictions using appropriate static and dynamic approaches (SimCyp) are desirable
  • Experience with toxicological predictions using tools such as DILI Sym/RenaSym for hepatic and renal toxicity respectively is highly desirable
  • Openness to fresh ideas and new perspectives to be gathered from working with people from diverse backgrounds and cultures.
  • Flexibility and keen pursuit of innovation throughout all phases of the drug discovery and development process
  • A desire to develop and grow by way of taking responsibility and engaging in additional tasks and operations.
  • Ability to work independently and deliver results in a timely manner
  • Publications in conference proceedings and peer-reviewed journals are encouraged
  • Excellent communication skills with the ability to translate and summarize outcomes of modeling and simulation analysis as relevant for discovery and development projects

Other Requirement: 

Normal and routine office duties
Position requires both domestic and international travel up to 20% of time

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We celebrate all dimensions of diversity and believe that it drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!
Apply now and become a part of our diverse team!

US Equal Employment Opportunities

The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law.  This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

We are committed to an equitable hiring process for candidates from a diverse range of backgrounds. As part of this commitment, applicants with disabilities may be entitled to reasonable accommodations. Please contact, if a reasonable accommodation is needed or if you otherwise need assistance to participate in the hiring process.

North America Disclosure

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