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130198 RonaCare® Cyclopeptide-5


About product information & SDS Downloads: All products shown on this website are based on the EU portfolio pursuant to applicable EU regulations. Safety Data Sheets (SDS) are currently not available for download via this website. Please contact our sales or customer service representative in the country.


Nowadays, the true richness lays in our skin. What is beneath the surface, is what makes the outcome a perfection.Keeping skin looking youthful means a constant support of all skin layers down where cells are communicating and working together. With time, this communication may be altered and become weaker.

This is where RonaCare® Cyclopeptide-5 comes into play. 


With RonaCare® Cyclopeptide-5, it’s easy. A bionic approach to trigger cell communication visibly improves the signs of aging and initiate the skin’s own repair mechanisms. 

Ready to turn back in time?

RonaCare® Cyclopeptide-5 is the first homodetic cyclic peptide for cosmetic applications. The active ingredient consists of a small number of amino acids mimicking the optimal key to unlock communication between cells and into the cells. This smart design ensures a high selectivity for its biological target – integrins at the RGD binding site. Integrins are those unique proteins which take care of the skin’s communication processes.

In vitro tests show that Cyclopeptide-5 inhibits harmful degradation enzymes of extracellular matrix (ECM) proteins like collagenase and elastase. On the other hand, it stimulates the stability of the extracellular matrix by activating fibulin, laminin, and collagen. Ex vivo and in vivo testing confirms that RonaCare® Cyclopeptide-5 supports greater skin elasticity and reduces the appearance of wrinkles after only a short period of use. The result is a more youthful, smoother appearance of the skin.

study results

  • 35%

    Increase of elastic fibers network - ex vivo study result

  • 16%

    Decrease in wrinkle depth at Crow’s feet - in vivo study result

  • 16%

    Increase in skin smoothness - in vivo study result

Advantages at a glance - Ronacare® Cyclopeptide-5

  • initiate repair processes via communication activation in the extracellular matrix 
  • protect the extracellular matrix structure 
  • smooth the skin while giving it back its firmness and elasticity 
  • reduce effectively the appearance of fine lines and wrinkles 
RonaCare® Cycplopeptide-5
See how Cyclopeptide-5 finds its way to the integrin pocket so that signaling can start - just like natural ligand fibronectin would do.


Aqua (Water), Alcohol, Lecithin, Ectoin, Cyclotetrapeptide-24 AminocyclohexaneCarboxylate

Active Ingredient tagged by:


Package Size

Product Number



1301982500 Glass bottle 2.5 kg
1301982501 Glass bottle 2.53 l

Product Information

GHS Labeling (according to EU REGULATION (EC) No 1272/2008 (CLP))

Hazard Pictogram
Signal Word Warning
Hazard Statement H226: Flammable liquid and vapour.
H319: Causes serious eye irritation.
Precautionary Statement P210: Keep away from heat.
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

Handling & Storage Information

Storage Temperature Store at +2°C to +30°C.
Storage class 3 Flammable liquids
WGK WGK 1 slightly hazardous to water

Physicochemical Information

Density 0.987 g/cm3 (20 °C)
pH value 4.9 - 6.9 (H₂O)
Flash point 34.1 °C