Christina Carbrello

As a scientist, it is both fun and rewarding to tackle a tough technical challenge and eventually see all of the pieces fall into place.

Perspective

I like to solve puzzles.  I never fail to be amazed by the way the world works.  As a scientist, it is both fun and rewarding to tackle a tough technical challenge and eventually see all of the pieces fall into place.  It is especially fun to work on these challenges with an intelligent and dynamic team that bring different ideas and expertise to the table, enabling us to figure things out that each of us could not do on our own.  

As a scientist, it is both fun and rewarding to tackle a tough technical challenge and eventually see all of the pieces fall into place.

Christina Carbrello

Principal Scientist

Profile

Joined Merck KGaA, Darmstadt, Germany: 2005

Key research fields and topics:

  • Virus filtration, membrane formation, membrane structure function relationships

Prizes and awards:

  • Millipore Technical Innovation Award

CV & Scientific activities

CV: Education

CV: Education

2005
Ph.D. Chemical Engineering, University of Wisconsin-Madison
1999
B.S. Chemical Engineering (Magna Cum Laude), University of Notre Dame

CV: Professional Career

CV: Professional Career

since 2018
Principal Scientist, MilliporeSigma
2009 - 2018
Senior Scientist, MilliporeSigma 
2005 - 2009
Research Scientist III, MilliporeSigma
1999 - 2005
Research Assistant, University of Wisconsin Department of Chemical and Biological Engineering   
Jun - Aug 2005
Project Assistant, Waisman Clinical Biomanufacturing Facility     
May - Aug 2001
Intern, Pfizer Global Research and Development (Ann Arbor, MI)
1998 - 1999
Undergraduate Research Assistant, University of Notre Dame Department of Chemical Engineering

Memberships

Memberships

  • Member of the Board of Directors of the North American Membrane Society: Nominations Committee chair (since 2018);
    Vice President (May 2019 - May 2020),
    President (May 2020 - May 2021)
  • Co-chair of the MilliporeSigma Life Science Award in Bioseparations (2015-present)
  • Member of the Industrial Advisory Board of the NSF IU-CRC for Membrane Science, Engineering and Technology, chair 2015
  • Award committee for the North American Membrane Society, 2014-present
  • Reviewer for the Journal of Membrane Science
  • Member of the American Chemical Society
  • Lab manager for Class 1, Div 1 Explosion Proof R&D casting lab
  • Millipore Technical Innovation Award
  • Biotechnology Training Grant Fellowship, 2003-2005
  • Pfizer Recognition Award, 2001
  • Wisconsin Distinguished Graduate Fellowship, 2005
  • 2001 Recipient of the Roland A. Ragatz award for excellent performance as Teaching Assistant, Spring 2001, Process Control Lab
  • Tau Beta Pi, Engineering Honor Society
  • London Engineering Summer Abroad Program, 1997

References

Publications

  • H. Nazem-Bokaee, F. Fallahianbijan, D. Chen, S.M. O’Donnell, C. Carbrello, S. Giglia, D. Bell, A.L. Zydney, “Probing pore structure of virus filters using scanning electron microscopy with gold nanoparticles”, Journal of Membrane Science 552 (2018), 144-152
  • W. Fu, C. Carbrello, X. Wu., W. Zhang, “Visualizing and quantifying the nanoscale hydrophobicity and chemical distribution of surface modified polyethersulfone (PES) membranes” Nanoscale, 9(40), 2017, 15550-15557
  • F. Fallahianbijan, S. Giglia, C. Carbrello, A.L. Zydney, “Use of fluorescently-labled nanoparticles to study pore morphology and virus capture in virus filtration membranes” Journal of Membrane Science 536 (2017), 52-58
  • H. Lutz, R. Wilkins, C. Carbrello, “Sterile Filtration Principles, Best Practices and New Developments” in Sterile Product Development: Formulation, Process, Delivery and Quality Challenges, P. Kolhe, M. Shah, and N. Rathore, eds., Springer, 2013
  • C. Bondy, C. Santeufemio “Analysis of fouling within microporous membranes in biopharmaceutical applications using latex microsphere suspensions” Journal of Membrane Science 349 (2010) 12-24 
  • C. Bondy, D. Siitari, T. Root, E. Lightfoot “Identification of Non-Idealities in Gel Electrophoresis”  Journal of Chromatograph A, 1080: (2005) 2-14 Jul 2005
  • D. Lafarga, M. Al-Juaied, C. Bondy, A. Varma “Ethylene epoxidation on Ag-Cs/-Al2O3 catalyst:  Experimental results and strategy for determining kinetic parameters” Industrial and Engineering Chemistry Research  39: (7) 2148-2156  Jul 2000

Selected Presentations

  • “Fundamental Studies of Virus Capture in Virus Filtration Membranes”, poster presentation with F. Fallahianbijan, S. Giglia, D. Bell and A.L. Zydney, Recovery of Biological Products, Asheville NC, October 2018
  • “Evaluation of Filterability of Cell Culture Media Components Using Virus Filtration”, with S. Guidetti, J. Grayham, R. Karcher, Annual Meeting of the North American Membrane Society, Lexington KY, June 2018
  • “Defend Your Bioreactor:  Using Nanofiltration to Prevent Virus Contamination of Cell Culture Processes”, PDA Europe Virus and TSE Safety Forum, Dubrovnik, Croatia, May 2017
  • “Preventing Virus Contamination of Bioreactors with a Virus Barrier Filter” Bioprocessing Summit, Boston, Massachusetts, August 2015
  • “Overcoming Bacterial Retention and Capacity Issues in Adjuvant Filtration” World Vaccine Congress, Washington DC, April 2009
  • “Analysis of Fouling in Microporous Membranes in Biopharmaceutical Applications” poster presentation with C. Santeufemio, American Chemical Society National Meeting, Philadelphia, Pennsylvania, August 2008
  • “Identification of Non-Idealities in Two-dimensional Gel Electrophoresis” with Thatcher W. Root and Edwin N. Lightfoot, American Chemical Society National Meeting, San Diego, California, March 2005
  • “Developing a Quantitative Understanding of Two-Dimensional Gel Electrophoresis” with David W. Siitari, Thatcher W. Root and Edwin N. Lightfoot, Annual Conference of the American Electrophoresis Society, Austin, Texas, November 2004
  • “Modeling Electrophoresis to Improve Gel Reproducibility” with Thatcher W. Root and Edwin N. Lightfoot, Annual Conference of the American Electrophoresis Society, Indianapolis, Indiana, November 2002

 

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