Christina Esdar

For my personal balance I like to do some sports which re-energizes my brain but brings also very often new ideas to my mind.

Perspective

Working in drug discovery in oncology is for sure challenging but also a real privilege. In my job, I have the great opportunity to apply my scientific education and my scientific curiosity to make a difference in cancer patients´ lives. I guess it is the biggest motivation for every scientist to contribute to a project that ultimately results into approval of a new cancer drug which helps patients. Each of our drug discovery projects comes with different challenges and questions. As a scientist, I am strongly committed to perform the right and critical experiments allowing data-driven decisions.

Furthermore, it is extremely rewarding for me to be part of a highly dedicated and engaged team in TIP Oncology. Our very collaborative and passionate spirit is creating an inspiring working atmosphere which keeps me motivated and excited about my work. For my personal balance I like to do some sports which re-energizes my brain but brings also very often new ideas to my mind. 

For my personal balance I like to do some sports which re-energizes my brain but brings also very often new ideas to my mind.

Christina Esdar

Head of Oncogenic Signaling Research in TIP Oncology

Profile

Joined Merck KGaA, Darmstadt, Germany: 2001

Key research fields and topics:

  • Novel therapeutic concepts in context of oncogenic driver alterations.
  • Target validation and mode of action analyses of potential new molecular entities in cell-based cancer models.
  • Identification and validation of pharmacodynamic and predictive biomarker.
  • Translation of preclinical drug discovery into clinical development.

CV & Scientific activities

References

List of publications

  • Herget T, Specht H, Esdar C, Oehrlein SA, Maelicke A., J Neurochem. 1998 Jan;70(1):47-58. PMID: 9422346
  • Esdar C, Oehrlein SA, Reinhardt S, Maelicke A, Herget T. Eur J Neurosci. 1999 Feb;11(2):503-16. PMID: 10051751
  • Herget T, Esdar C, Oehrlein SA, Heinrich M, Schütze S, Maelicke A, van Echten-Deckert G. J Biol Chem. 2000 Sep 29;275(39):30344-54. PMID: 10862608
  • Esdar C, Milasta S, Maelicke A, Herget T. Eur J Cell Biol. 2001 Aug;80(8):539-53. PMID: 11561905
  • Mett H, Hölscher K, Degen H, Esdar C, De Neumann BF, Flicke B, Freudenreich T, Holzer G, Schinzel S, Stamminger T, Stein-Gerlach M, Marschall M, Herget T.  J Biomol Screen. 2005 Feb;10(1):36-45. PMID: 15695342
  • Heinrich T, Seenisamy J, Emmanuvel L, Kulkarni SS, Bomke J, Rohdich F, Greiner H, Esdar C, Krier M, Grädler U, Musil D. J Med Chem. 2013 Feb 14;56(3):1160-70. doi: 10.1021/jm3016014. Epub 2013 Jan 22. PMID: 23294348
  • Grädler U, Bomke J, Musil D, Dresing V, Lehmann M, Hölzemann G, Greiner H, Esdar C, Krier M, Heinrich T. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5401-9. doi: 10.1016/j.bmcl.2013.07.050. Epub 2013 Jul 31. PMID: 23973211
  • Mallinger A, Crumpler S, Pichowicz M, Waalboer D, Stubbs M, Adeniji-Popoola O, Wood B, Smith E, Thai C, Henley AT, Georgi K, Court W, Hobbs S, Box G, Ortiz-Ruiz MJ, Valenti M, De Haven Brandon A, TePoele R, Leuthner B, Workman P, Aherne W, Poeschke O, Dale T, Wienke D, Esdar C, Rohdich F, Raynaud F, Clarke PA, Eccles SA, Stieber F, Schiemann K, Blagg J. J Med Chem. 2015 Feb 26;58(4):1717-35. doi: 10.1021/jm501436m. Epub 2015 Feb 13. PMID: 25680029
  • Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J. Nat Chem Biol. 2015 Dec;11(12):973-980. doi: 10.1038/nchembio.1952. Epub 2015 Oct 26. PMID:26502155
  • Mallinger A, Schiemann K, Rink C, Stieber F, Calderini M, Crumpler S, Stubbs M, Adeniji-Popoola O, Poeschke O, Busch M, Czodrowski P, Musil D, Schwarz D, Ortiz-Ruiz MJ, Schneider R, Thai C, Valenti M, de Haven Brandon A, Burke R, Workman P, Dale T, Wienke D, Clarke PA, Esdar C, Raynaud FI, Eccles SA, Rohdich F, Blagg J. J Med Chem. 2016 Feb 11;59(3):1078-101. doi: 10.1021/acs.jmedchem.5b01685. Epub 2016 Jan 21 PMID:26796641
  • Schiemann K, Mallinger A, Wienke D, Esdar C, Poeschke O, Busch M, Rohdich F, Eccles SA, Schneider R, Raynaud FI, Czodrowski P, Musil D, Schwarz D, Urbahns K, Blagg J. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1443-51. doi: 10.1016/j.bmcl.2016.01.062. Epub 2016 Jan 22.  PMID: 26852363
  • Wucherer-Plietker M, Merkul E, Müller TJ, Esdar C, Knöchel T, Heinrich T, Buchstaller HP, Greiner H, Dorsch D, Finsinger D, Calderini M, Bruge D, Grädler U. Bioorg Med Chem Lett. 2016 Jul 1;26(13):3073-80. doi: 10.1016/j.bmcl.2016.05.005. Epub 2016 May 4. PMID: 27217002
  • Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, Holman P, Howard H, Miyamoto J, Porras P, Walterscheid Z, Schultz-Fademrecht C, Esdar C, Schadt O, Eickhoff J, Lowy AM. Oncotarget. 2016 Jul 19;7(29):45959-45975. doi: 10.18632/oncotarget.10009. PMID:27323855
  • Mallinger A, Schiemann K, Rink C, Sejberg J, Honey MA, Czodrowski P, Stubbs M, Poeschke O, Busch M, Schneider R, Schwarz D, Musil D, Burke R, Urbahns K, Workman P, Wienke D, Clarke PA, Raynaud FI, Eccles SA, Esdar C, Rohdich F, Blagg J. ACS Med Chem Lett. 2016 Mar 28;7(6):573-8. doi: 10.1021/acsmedchemlett.6b00022. eCollection 2016 Jun 9. PMID: 27326329
  • Czodrowski P, Mallinger A, Wienke D, Esdar C, Poeschke O, Busch M, Rohdich F, Eccles SA, Ortiz Ruiz MJ, Schneider R, Raynaud FI, Clarke PA, Musil D, Schwarz D, Dale TC, Urbahns K, Blagg J, Schiemann K. J Med Chem. Oct 27;59(20):9337-9349. Epub 2016 Oct 7. PMID:27490956
  • Clarke PA, Ortiz-Ruiz MJ, TePoele R, Adeniji-Popoola O, Box G, Court W, Czasch S, El Bawab S, Esdar C, Ewan K, Gowan S, De Haven Brandon A, Hewitt P, Hobbs SM, Kaufmann W, Mallinger A, Raynaud F, Roe T, Rohdich F, Schiemann K, Simon S, Schneider R, Valenti M, Weigt S, Blagg J, Blaukat A, Dale TC, Eccles SA, Hecht S, Urbahns K, Workman P, Wienke D. Elife. 2016 Dec 9;5. pii: e20722. doi: 10.7554/eLife.20722. PMID: 27935476
  • Poetz O, Dieze T, Hammer H, Weiß F, Sommersdorf C, Templin MF, Esdar C, Zimmermann A, Stevanovic S, Bedke J, Stenzl A, Joos TO. Anal Chem. 2018 May 1;90(9):5788-5794. doi: 10.1021/acs.analchem.8b00152. Epub 2018 Apr 12. PMID:29570278 
  • Menon M, Elliott R, Bowers L, Balan N, Rafiq R, Costa-Cabral S, Munkonge F, Trinidade I, Porter R, Campbell AD, Johnson ER, Esdar C, Buchstaller HP, Leuthner B, Rohdich F4 Schneider R, Sansom O, Wienke D, Ashworth A, Lord CJ. A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors. Sci.Rep. 2019, 9(1):201.
  • Buchstaller HP, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R, Esdar C.  Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity. J Med Chem. 2019, 62(17), 7897-7909 

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