Dieter Lubda

Products based on great ideas can only be developed on a lab bench and produced in a powerful production facility. Head Actives & Formulation R&D Operations.


Perspective

Our company was in 1984 the company of choice for me as Merck KGaA, Darmstadt, Germany was known to be a very innovative, stable and value living company. During my education and former work with Schering AG in West Berlin and my academic education at University Berlin and Vienna/Austria I already made experience with the high quality raw materials delivered by our company, as well as using at that time the Merck KGaA, Darmstadt, Germany catalog as compendium to find all product information needed. 

During my career working with Merck KGaA, Darmstadt, Germany I always recognized and appreciated the open and supportive atmosphere and the powerful network within our company giving me a strong backbone for my scientific work and all kinds of product developments. Failures were always possible, and in R&D it is important to have such a commitment in the company (or better to say to have the courage), without being afraid about personal consequences. Merck KGaA, Darmstadt, Germany always offered a working environment of a good mixture of strong product development with space for innovation and curiosity and persistence of the scientific thinking colleagues. In addition, the management very much supported to work with partners from academia and other companies to find new ideas or to speed up developments using external knowledge. Such internal and external innovative minds were very much promoted after the Innovation Center was established, giving our company a good opportunity to seed curiosity and new ideas. 

This brings me to one very important aspect of my vision and motivation for the future of our company. Of cause it’s not only to have great ideas, but very much important is to preserve and extend the internal knowledge about own processes and technologies as well as about technical advantages of products offered within our portfolio, supporting our customers daily work and efficiency of their own developments. Products based on great ideas can only be developed on a lab bench and produced in a powerful production facility. In combination with our strong analytical and regulatory capability and good trained and skilled peoples in all parts of the company it is a good base for our future success.

I recognize within our fast-changing world and customer environment more and more the trend, due to lack of time or because of other reasons, that products, instruments and technologies are very often not used most efficiently. Developers in R&D and production often do not have enough knowhow and time to plan their activities or read scientific papers and combine the tools available in such a way to make the products and technologies work best. For our company this is a big chance to support and become thought leader within such scientific fields. My big motivation is that in R&D of A&F I have the chance, by working on the challenge of drug delivery (e.g. solubility and bioavailability of drugs), to solve some of the toughest problems in Life Science. With our work we can make the world better for a lot of peoples by accelerate access to health globally.

Products based on great ideas can only be developed on a lab bench and produced in a powerful production facility.

Dieter Lubda

Head Actives & Formulation R&D Operations

Profile

Joined Merck KGaA, Darmstadt, Germany: 1984

Key research fields and topics:

  • Development of Excipients for formulation of APIs (Active Pharmaceutical Ingredients)
  • Drug delivery technologies to support solubilities and bioavailability of APIs 
  • Focus oral, transdermal delivery, inhalation with contacts to subcutaneous and i.v. (Excipients/ PEGs and lipids 
  • Preparation of monolithic structures to be used as separation materials or for alternative applications
  • Development of micro and nano-carrier materials for different application fields
  • Design of structures, porosity and surface modification of inorganic carrier materials with focus on carrier in Chromatography
  • Experience in needs and requirements to transfer products from development to operations 

Prizes and awards:

Awards given to Dieter Lubda in person or part of the development team:

  • CPhI 2018 Award Parteck® MXP: Excipient for Hot Melt Extrusion winning the 2018 CPhI Excellence in Pharma: Excipients Award (Part of the development group of the product)
  • 2017 IPEC Foundation’s Industry Research Achievement in Excipient Technology Award (USA). Merck KGaA, Darmstadt, Germany’s own Dr. Dieter Lubda was awarded by the IPEC Foundation the charitable arm of IPEC-Americas.
  • CPhI 2016 Award Parteck® SRP 80: Price for Excellence in Pharma: Formulation and Excipients. (Part of the development group of the product)
  • CPhI 2012 Award: Parteck® SLC: An innovative silica drug carrier that was awarded the Silver Prize at the 2012 CPhI Pharma Awards. (Part of the development group of the product)
  • German Industry Innovation Award 2002 – One of 5 most important innovations in 2002 (Preis der deutschen Wirtschaft /Given to the development team Chromolith® capillaries)
  • Pittcon Gold Award 2001 (USA Awards) - Best Product 2001Pittcon editors Gold Award went to the Chromolith® HPLC columns from Merck KGaA, Darmstadt, Germany
  • R&D 100 Award 2001 (USA Awards) – One of the 100 most important innovations in 2001. Honoring great R&D pioneers and their revolutionary ideas in science and technology(Given for the development of Chromolith Speed ROD RP-18e and Chromolith Performance RP-18e)
  • German Industry Innovation Award 2001 – One of 5 most important innovations in 2001 (Preis der deutschen Wirtschaft = INNOVATIONSPREIS der deutschen Wirtschaft - Erster Innovationspreis der Welt /Given to the development team of Chromolith® products)
  • Merck KGaA, Darmstadt, Germany Innovation Award 2000 / For the Silica Rod project team

CV & Scientific activities

CV: Education

CV: Education

CV: Professional Career

CV: Professional Career

References

Publications

Awards given to Dieter Lubda in person or part of the development team:

Most important peer-reviewed papers found by Scopus®:

  • Nguyen, H.X., Bozorg, B.D., Kim, Y., Wieber, A., Birk, G., Lubda, D., Banga, A.K.Poly (vinyl alcohol) microneedles: Fabrication, characterization, and application for transdermal drug delivery of doxorubicin(2018) European Journal of Pharmaceutics and Biopharmaceutics, 129, pp. 88-103. Cited 1 time.
  • O'Shea, J.P., Nagarsekar, K., Wieber, A., Witt, V., Herbert, E., O'Driscoll, C.M., Saal, C., Lubda, D., Griffin, B.T., Dressman, J.B.Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: caseexample fenofibrate(2017) Journal of Pharmacy and Pharmacology, 69 (10), pp. 1284-1292. Cited 2 times.
  • Sivaraman, A., Ganti, S.S., Nguyen, H.X., Birk, G., Wieber, A., Lubda, D., Banga, A.K.Development and evaluation of a polyvinyl alcohol based topical gel(2017) Journal of Drug Delivery Science and Technology, 39, pp. 210-216. Cited 7 times.
  • Dressman, J.B., Herbert, E., Wieber, A., Birk, G., Saal, C., Lubda, D. Mesoporous silica-based dosage forms improve release characteristics of poorly soluble drugs: Case example fenofibrate(2016) Journal of Pharmacy and Pharmacology, 68 (5), pp. 634-645. Cited 5 times.
  • LaFountaine, J.S., Jermain, S.V., Prasad, L.K., Brough, C., Miller, D.A., Lubda, D., McGinity, J.W., Williams, R.O.Enabling thermal processing of ritonavir-polyvinyl alcohol amorphous solid dispersions by KinetiSol® Dispersing(2016) European Journal of Pharmaceutics and Biopharmaceutics, 101, pp. 72-81. Cited 11 times.
  • Brough, C., Miller, D.A., Ellenberger, D., Lubda, D., Williams, R.O.Use of Polyvinyl Alcohol as a Solubility Enhancing Polymer for Poorly Water-Soluble Drug Delivery (Part 2)(2016) AAPS PharmSciTech, 17 (1), pp. 180-190. Cited 7 times.
  • Brough, C., Miller, D.A., Keen, J.M., Kucera, S.A., Lubda, D., Williams, R.O.Use of Polyvinyl Alcohol as a Solubility-Enhancing Polymer for Poorly Water Soluble Drug Delivery (Part 1)(2016) AAPS PharmSciTech, 17 (1), pp. 167-179. Cited 18 times.
  • Gotti, R., Fiori, J., Calleri, E., Temporini, C., Lubda, D., Massolini, G.Chiral capillary liquid chromatography based on penicillin G acylase immobilized on monolithic epoxy silica column(2012) Journal of Chromatography A, 1234, pp. 45-49. Cited 19 times.
  • Buchinger, S., Follrich, B., Lämmerhofer, M., Lubda, D., Lindner, W.Chirally functionalized anion-exchange type silica monolith for enantiomer separation of 2-aryloxypropionic acid herbicides by nonaqueous capillary electrochromatography(2009) Electrophoresis, 30 (22), pp. 3804-3813. Cited 16 times.
  • Machtejevras, E., Marko-Varga, G., Lindberg, C., Lubda, D., Hendriks, R., Unger, K.K.Profiling of endogenous peptides by multidimensional liquid chromatography: On-line automated sample cleanup for biomarker discovery in human urine(2009) Journal of Separation Science, 32 (13), pp. 2223-2232. Cited 16 times.
  • Kagan, M., Chlenov, M., Melnikov, S., McConnell, O., Bach II, A.C., Carter, G., Failli, A., Caggiano, T.J., Shumsky, J.S., Lubda, D. Normal-phase automated mass-directed HPLC purification of a pyrrolobenzodiazepine library with vasopressin agonist activity(2009) Journal of Combinatorial Chemistry, 11 (4), pp. 704-719. Cited 9 times.
  • Thommes, M., Skudas, R., Unger, K.K., Lubda, D. Textural characterization of native and N-alky-bonded silica monoliths by mercury intrusion/extrusion, inverse size exclusion chromatography and nitrogen adsorption(2008) AIChE Annual Meeting, Conference Proceedings, 1 p.Document Type: Conference Paper
  • Preinerstorfer, B., Lämmerhofer, M., Hoffmann, C.V., Lubda, D., Lindner, W.Deconvolution of electrokinetic and chromatographic contributions to solute migration in stereoselective ion-exchange capillary electrochromatography on monolithic silica capillary columns(2008) Journal of Separation Science, 31 (16-17), pp. 3065-3078. Cited 21 times.
  • Thommes, M., Skudas, R., Unger, K.K., Lubda, D. Textural characterization of native and n-alky-bonded silica monoliths by mercury intrusion/extrusion, inverse size exclusion chromatography and nitrogen adsorption(2008) Journal of Chromatography A, 1191 (1-2), pp. 57-66. Cited 30 times.
  • Preinerstorfer, B., Hoffmann, C., Lubda, D., Lämmerhofer, M., Lindner, W.Enantioselective silica-based monoliths modified with a novel aminosulfonic acid-derived strong cation exchanger for electrically driven and pressure-driven capillary chromatography(2008) Electrophoresis, 29 (8), pp. 1626-1637. Cited 23 times.
  • Grimes, B.A., Skudas, R., Unger, K.K., Lubda, D. Pore structural characterization of monolithic silica columns by inverse size-exclusion chromatography(2007) Journal of Chromatography A, 1144 (1), pp. 14-29. Cited 34 times.
  • Machtejevas, E., Andrecht, S., Lubda, D., Unger, K.K.Monolithic silica columns of various format in automated sample clean-up/multidimensional liquid chromatography/mass spectrometry for peptidomics(2007) Journal of Chromatography A, 1144 (1), pp. 97-101. Cited 26 times.
  • Skudas, R., Grimes, B.A., Machtejevas, E., Kudirkaite, V., Kornysova, O., Hennessy, T.P., Lubda, D., Unger, K.K.Impact of pore structural parameters on column performance and resolution of reversed-phase monolithic silica columns for peptides and proteins(2007) Journal of Chromatography A, 1144 (1), pp. 72-84. Cited 20 times.
  • Temporini, C., Perani, E., Calleri, E., Dolcini, L., Lubda, D., Caccialanza, G., Massolini, G.Pronase-immobilized enzyme reactor: An approach for automation in glycoprotein analysis by LC/LC-ESI/MSn(2007) Analytical Chemistry, 79 (1), pp. 355-363. Cited 62 times.
  • Preinerstorfer, B., Lubda, D., Mucha, A., Kafarski, P., Lindner, W., Lämmerhofer, M.Stereoselective separations of chiral phosphinic acid pseudodipeptides by CEC using silica monoliths modified with an anion-exchange-type chiral selector(2006) Electrophoresis, 27 (21), pp. 4312-4320. Cited 31 times.
  • Machtejevas, E., Denoyel, R., Meneses, J.M., Kudirkaite, V., Grimes, B.A., Lubda, D., Unger, K.K.Sulphonic acid strong cation-exchange restricted access columns in sample cleanup for profiling of endogeneous peptides in multidimensional liquid chromatography. Structure and function of strong cation-exchange restricted access materials(2006) Journal of Chromatography A, 1123 (1), pp. 38-46. Cited 16 times.
  • Rieux, L., Lubda, D., Niederländer, H.A.G., Verpoorte, E., Bischoff, R.Fast, high-efficiency peptide separations on a 50-μm reversed-phase silica monolith in a nanoLC-MS set-up(2006) Journal of Chromatography A, 1120 (1-2), pp. 165-172. Cited 29 times.
  • Temporini, C., Perani, E., Mancini, F., Bartolini, M., Calleri, E., Lubda, D., Felix, G., Andrisano, V., Massolini, G.Optimization of a trypsin-bioreactor coupled with high-performance liquid chromatography-electrospray ionization tandem mass spectrometry for quality control of biotechnological drugs(2006) Journal of Chromatography A, 1120 (1-2), pp. 121-131. Cited 46 times.
  • Nogueira, R., Lubda, D., Leitner, A., Bicker, W., Maier, N.M., Lämmerhofer, M., Lindner, W.Silica-based monolithic columns with mixed-mode reversed-phase/weak anion-exchange selectivity principle for high-performance liquid chromatography(2006) Journal of Separation Science, 29 (7), pp. 966-978. Cited 52 times.
  • Preinerstorfer, B., Lubda, D., Lindner, W., Lämmerhofer, M.Monolithic silica-based capillary column with strong chiral cation-exchange type surface modification for enantioselective non-aqueous capillary electrochromatography(2006) Journal of Chromatography A, 1106 (1-2), pp. 94-105. Cited 53 times.
  • Shen, Y., Strittmatter, E.F., Zhang, R., Metz, T.O., Moore, R.J., Li, F., Udseth, H.R., Smith, R.D., Unger, K.K., Kumar, D., Lubda, D. Making broad proteome protein measurements in 1-5 min using high-speed RPLC separations and high-accuracy mass measurements(2005) Analytical Chemistry, 77 (23), pp. 7763-7773. Cited 26 times.
  • Droste, S., Schellenträger, M., Constapel, M., Gäb, S., Lorenz, M., Brockmann, K.J., Benter, T., Lubda, D., Schmitz, O.J.A silica-based monolithic column in capillary HPLC and CEC coupled with ESI-MS or electrospray-atmospheric-pressure laser ionization-MS(2005) Electrophoresis, 26 (21), pp. 4098-4103. Cited 19 times.
  • Shen, Y., Smith, R.D., Unger, K.K., Kumar, D., Lubda, D.Ultrahigh-throughput proteomics using fast RPLC separations with ESI-MS/MS(2005) Analytical Chemistry, 77 (20), pp. 6692-6701. Cited 63 times.
  • Lubda, D., Lindner, W., Quaglia, M., Von Hohenesche, C.D.F., Unger, K.K.Comprehensive pore structure characterization of silica monoliths with controlled mesopore size and macropore size by nitrogen sorption, mercury porosimetry, transmission electron microscopy and inverse size exclusion chromatography(2005) Journal of Chromatography A, 1083 (1-2), pp. 14-22. Cited 64 times.
  • Vintiloiu, A., Mullett, W.M., Papp, R., Lubda, D., Kwong, E.Combining restricted access material (RAM) and turbulent flow for the rapid on-line extraction of the cyclooxygenase-2 inhibitor rofecoxib in plasma samples(2005) Journal of Chromatography A, 1082 (2), pp. 150-157. Cited 34 times.
  • Lambert, J.-P., Mullett, W.M., Kwong, E., Lubda, D.Stir bar sorptive extraction based on restricted access material for the direct extraction of caffeine and metabolites in biological fluids(2005) Journal of Chromatography A, 1075 (1-2), pp. 43-49. Cited 108 times.
  • Hennessy, T.P., Quaglia, M., Kornyšova, O., Grimes, B.A., Lubda, D., Unger, K.K.Dynamic electric field assisted multi-dimensional liquid chromatography of biological samples(2005) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,817 (1), pp. 127-137. Cited 5 times.
  • Walles, M., Gu, Y., Dartiguenave, C., Musteata, F.M., Waldron, K., Lubda, D., Pawliszyn, J.Approaches for coupling solid-phase microextraction to nanospray(2005) Journal of Chromatography A, 1067 (1-2), pp. 197-205. Cited 29 times.
  • Calleri, E., Temporini, C., Perani, E., De Palma, A., Lubda, D., Mellerio, G., Sala, A., Galliano, M.,Caccialanza, G., Massolini, G.Trypsin-based monolithic bioreactor coupled on-line with LC/MS/MS system for protein digestion and variant identification in standard solutions and serum samples(2005) Journal of Proteome Research, 4 (2), pp. 481-490. Cited 76 times.
  • Rbeida, O., Christiaens, B., Hubert, Ph., Lubda, D., Boos, K.-S., Crommen, J., Chiap, P.Integrated on-line sample clean-up using cation exchange restricted access sorbent for the LC determination of atropine in human plasma coupled to UV detection(2005) Journal of Pharmaceutical and Biomedical Analysis, 36 (5), pp. 947-954. Cited 37 times.
  • Rbeida, O., Chiap, P., Lubda, D., Boos, K.-S., Crommen, J., Hubert, Ph.Development and validation of a fully automated LC method for the determination of cloxacillin in human plasma using anion exchange restricted access material for sample clean-up(2005) Journal of Pharmaceutical and Biomedical Analysis, 36 (5), pp. 961-968. Cited 29 times.
  • Calleri, E., Marrubini, G., Massolini, G., Lubda, D., De Fazio, S.S., Furlanetto, S., Wainer, I.W., Manzo, L., Caccialanza, G.Development of a chromatographic bioreactor based on immobilized β-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine(2004) Journal of Pharmaceutical and Biomedical Analysis, 35 (5), pp. 1179-1189. Cited 17 times.
  • Calleri, E., Temporini, C., Perani, E., Stella, C., Rudaz, S., Lubda, D., Mellerio, G., Veuthey, J.-L., Caccialanza, G., Massolini, G.Development of a bioreactor based on trypsin immobilized on monolithic support for the on-line digestion and identification of proteins(2004) Journal of Chromatography A, 1045 (1-2), pp. 99-109. Cited 110 times.
  • Félix, G., Cabrera, K., Lubda, D., Roussel, J.-M., Siouffi, A.M.Polyhydrogenosiloxanes: Powerful tools for silanization of commercial monolithic rods(2004) Chromatographia, 60 (1-2), pp. 3-8. Cited 3 times.
  • Lubda, D., Lindner, W.Monolithic silica columns with chemically bonded tert-butylcarbamoylquinine chiral anion-exchanger selector as a stationary phase for enantiomer separations(2004) Journal of Chromatography A, 1036 (2), pp. 135-143. Cited 58 times.
  • Huber, M.I., Hennessy, T.P., Lubda, D., Unger, K.K.Evaluation and comparison of tailor-made stationary phases based on spherical silica-based beads for capillary electrochromatography via peptide separation analysis(2004) Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences,803 (1), pp. 137-147. Cited 6 times.
  • Calleri, E., Massolini, G., Lubda, D., Temporini, C., Loiodice, F., Caccialanza, G.Evaluation of a monolithic epoxy silica support for penicillin G acylase immobilization(2004) Journal of Chromatography A, 1031 (1-2), pp. 93-100. Cited 72 times.
  • Rbeida, O., Christiaens, B., Hubert, Ph., Lubda, D., Boos, K.-S., Crommen, J., Chiap, P.Evaluation of a novel anion-exchange restricted-access sorbent for on-line sample clean-up prior to the determination of acidic compounds in plasma by liquid chromatography(2004) Journal of Chromatography A, 1030 (1-2), pp. 95-102. Cited 46 times.
  • Leinweber, F.C., Schmid, D.G., Lubda, D., Sontheimer, B., Jung, G., Tallarek, U.Sheathless electrospray ionization directly from a capillary monolith for fast liquid chromatography coupled to Fourier transform ion cyclotron resonance mass spectrometry(2004) Journal of Mass Spectrometry, 39 (2), pp. 223-225. Cited 6 times.
  • Lubda, D., Cabrera, K., Nakanishi, K., Lindner, W.Monolithic silica columns with chemically bonded β-cyclodextrin as a stationary phase for enantiomer separations of chiral pharmaceuticals(2003) Analytical and Bioanalytical Chemistry, 377 (5), pp. 892-901. Cited 68 times.
  • Barroso, B., Lubda, D., Bischoff, R.Applications of Monolithic Silica Capillary Columns in Proteomics(2003) Journal of Proteome Research, 2 (6), pp. 633-642. Cited 40 times.
  • Rbeida, O., Christiaens, B., Chiap, P., Hubert, Ph., Lubda, D., Boos, K.-S., Crommen, J.Fully automated LC method for the determination of sotalol in human plasma using restricted access material with cation exchange properties for sample clean-up(2003) Journal of Pharmaceutical and Biomedical Analysis, 32 (4-5), pp. 829-838. Cited 41 times.
  • Leinweber, F.C., Schmid, D.G., Lubda, D., Wiesmüller, K.-H., Jung, G., Tallarek, U.Silica-based monoliths for rapid peptide screening by capillary liquid chromatography hyphenated with electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry(2003) Rapid Communications in Mass Spectrometry, 17 (11), pp. 1180-1188. Cited 30 times.
  • Massolini, G., Calleri, E., Lavecchia, A., Loiodice, F., Lubda, D., Temporini, C., Fracchiolla, G., Tortorella, P., Novellino, E., Caccialanza, G.Enantioselective hydrolysis of some 2-aryloxyalkanoic acid methyl esters and isosteric analogues using a penicillin G acylase-based HPLC monolithic silica column(2003) Analytical Chemistry, 75 (3), pp. 535-542. Cited 46 times.
  • Chiap, P., Rbeida, O., Christiaens, B., Hubert, Ph., Lubda, D., Boos, K.-S., Crommen, J.Use of a novel cation-exchange restricted-access material for automated sample clean-up prior to the determination of basic drugs in plasma by liquid chromatography(2002) Journal of Chromatography A, 975 (1), pp. 145-155. Cited 62 times.
  • Mullett, W.M., Levsen, K., Lubda, D., Pawliszyn, J.Bio-compatible in-tube solid-phase microextraction capillary for the direct extraction and high-performance liquid chromatographic determination of drugs in human serum(2002) Journal of Chromatography A, 963 (1-2), pp. 325-334. Cited 86 times.
  • Leinweber, F.C., Lubda, D., Cabrera, K., Tallarek, U.Characterization of silica-based monoliths with bimodal pore size distribution(2002) Analytical Chemistry, 74 (11), pp. 2470-2477. Cited 155 times.
  • Unger, K.K., Bidlingmaier, B., Du Fresne von Hohenesche, C., Lubda, D.Evaluation and comparison of the pore structure and related properties of particulate and monolithic silicas for liquid phase separation processes(2002) Studies in Surface Science and Catalysis, 144, pp. 115-122. Cited 7 times.
  • Lubda, D., Cabrera, K., Kraas, W., Schaefer, C., Cunningham, D., Majors, R.E.New developments in the application of monolithic HPLC columns(2001) LC-GC North America, 19 (12), pp. 1186-1191. Cited 22 times.
  • Schäfer, C., Cabrera, K., Lubda, D., Sinz, K., Cunningham, D.HPLC columns: The next great leap forward - Part 2(2001) American Laboratory, 33 (9), pp. 25-26. Cited 6 times.
  • Schäfer, C., Lubda, D.Alkyl diol silica: Restricted access pre-column packings for fast liquid chromatography-integrated sample preparation of biological fluids(2001) Journal of Chromatography A, 909 (1), pp. 73-78. Cited 57 times.
  • Cabrera, K., Lubda, D., Sinz, K., Schäfer, C.HPLC columns: The next great leap forward - Part 1(2001) American Laboratory, 33 (4), pp. 40-41. Cited 11 times.
  • Lubda, D., Cabrera, K., Kraas, W., Schaefer, C., Cunningham, D., Majors, R.E.New Developments in the Application of Monolithic HPLC Columns(2001) LC GC Europe, 14 (12), pp. 730-734. Cited 36 times.
  • Rabel, F., Cabrera, K., Lubda, D.Advancing separation science with monolithic silica HPLC columns(2000) American Laboratory, 32 (24), pp. 20-22. Cited 18 times.
  • Schulte, M., Lubda, D., Delp, A., Dingenen, J.Preparative monolithic silica sorbents (PrepRODs™) and their use in preparative liquid chromatography(2000) Journal of Separation Science, 23 (1), pp. 100-105. Cited 8 times.
  • Cabrera, K., Lubda, D., Eggenweiler, H.-M., Minakuchi, H., Nakanishi, K.A new monolithic-type HPLC column for fast separations(2000) Journal of Separation Science, 23 (1), pp. 93-99. Cited 52 times.
  • Tanaka, N., Nagayama, H., Kobayashi, H., Ikegami, T., Hosoya, K., Ishizuka, N., Minakuchi, H., Nakanishi, K., Cabrera, K., Lubda, D.Monolithic silica columns for HPLC, micro-HPLC, and CEC(2000) Journal of Separation Science, 23 (1), pp. 111-116. Cited 32 times.
  • Račaityte, K., Lutz, E.S.M., Unger, K.K., Lubda, D., Boos, K.S.Analysis of neuropeptide Y and its metabolites by high-performance liquid chromatography-electrospray ionization mass spectrometry and integrated sample clean-up with a novel restricted-access sulphonic acid cation exchanger(2000) Journal of Chromatography A, 890 (1), pp. 135-144. Cited 40 times.
  • Tanaka, N., Nagayama, H., Kobayashi, H., Ikegami, T., Hosoya, K., Ishizuka, N., Minakuchi, H., Nakanishi, K., Cabrera, K., Lubda, D.Monolithic columns(2000) HRC Journal of High Resolution Chromatography, 23 (1), p. 1. Cited 2 times.
  • Schulte, M., Lubda, D., Delp, A., Dingenen, J.Preparative monolithic silica sorbents (PrepRODs(TM)) and their use in preparative liquid chromatography(2000) HRC Journal of High Resolution Chromatography, 23 (1), pp. 100-105. Cited 39 times.
  • Cabrera, K., Lubda, D., Eggenweiler, H.-M., Minakuchi, H., Nakanishi, K.A new monolithic-type HPLC column for fast separations(2000) HRC Journal of High Resolution Chromatography, 23 (1), pp. 93-99. Cited 228 times.
  • Zöllner, P., Leitner, A., Lubda, D., Cabrera, K., Lindner, W.Application of a Chromolith SpeedROD RP-18e HPLC column: Determination of ochratoxin A in different wines by high-performance liquid chromatography-tandem mass spectrometry(2000) Chromatographia, 52 (11-12), pp. 818-820. Cited 78 times.
  • Tanaka, N., Nagayama, H., Kobayashi, H., Ikegami, T., Hosoya, K., Ishizuka, N., Minakuchi, H., Nakanishi, K., Cabrera, K., Lubda, D.Monolithic silica columns for HPLC, micro-HPLC, and CEC(2000) HRC Journal of High Resolution Chromatography, 23 (1), pp. 111-116. Cited 256 times.
  • Spange, S., Reuter, A., Lubda, D.ET(30) surface polarity parameters of alkyl- and aryl-group-functionalized silica particles: Differentiating the surface environments by means of the application of differently substituted Reichardt's dyes(1999) Langmuir, 15 (6), pp. 2103-2111. Cited 51 times.
  • Grimm, C.-H., Boos, K.-S., Lubda, D.Practical guidelines for HPLC-integrated clean-up of biological samples using column switching and restricted access precolumn packings(1998) Journal de Pharmacie de Belgique, 53 (3), p. 191. Cited 1 time.
  • Lubda, D., Cabrera, K., Wieland, G., Ishizuka, N., Soga, N., Minakuchi, H., Nakanishi, K.Silicarod colomns a new approach for speeding up analytical separations(1998) Journal de Pharmacie de Belgique, 53 (3), p. 216.
  • Strohschein, S., Pursch, M., Lubda, D., Albert, K.Shape Selectivity of C30 Phases for RP-HPLC Separation of Tocopherol Isomers and Correlationwith MAS NMR Data from Suspended Stationary Phases(1998) Analytical Chemistry, 70 (1), pp. 13-18. Cited 108 times.
  • Cabrera, K., Wieland, G., Lubda, D., Nakanishi, K., Soga, N., Minakuchi, H., Unger, K.K.SilicaROD(TM) - A new challenge in fast high-performance liquid chromatography separations(1998) TrAC - Trends in Analytical Chemistry, 17 (1), pp. 50-53. Cited 117 times.
  • Cabrera, K., Arras, R., Lubda, D., Krebs, K.-F., Wieland, G.Preparation and chromatographic characterization of a new stationary phase for reversed-phase HPLC based on a high-purity silica(1997) American Laboratory, 29 (4), pp. 44-50. Cited 4 times.
  • Majors, R.E., Boos, K.-S., Grimm, C.-H., Lubda, D., Wieland, G.Practical guidelines for HPLC-integrated sample preparation using column switching(1996) LC GC: Liquid Chromatography, Gas Chromatography, 14 (7), pp. 554-560. Cited 48 times.
  • Boos, K.-S., Rudolphi, A., Vielhauer, S., Walfort, A., Lubda, D., Eisenbeiß, F.Alkyl-Diol Silica (ADS): restricted access precolumn packings for direct injection and coupled-column chromatography of biofluids(1995) Fresenius' Journal of Analytical Chemistry, 352 (7-8), pp. 684-690. Cited 112 times.
  • Cabrera, K., Lubda, D.Influence of temperature on chiral high-performance liquid chromatographic separations of oxazepam and Prominal on chemically bonded β-cyclodextrin as stationary phase(1994) Journal of Chromatography A, 666 (1-2), pp. 433-438. Cited 59 times.

Patents:

114 Patents pending and 53 Patent granted as results found in the Worldwide database for Lubda as the inventor

  1. Glycine particlesPublication info: AU2017222125 (A1) 2018-10-11
  2. SOLID DISPERSIONS OF COMPOUNDS USING POLYVINYL ALCOHOL AS A CARRIER POLYMERPublication info: US2018280302 (A1) 2018-10-04
  3. TABLETS HAVING MEDIA INDEPENDENT ACTIVE SUBSTANCE DELIVERYPublication info: US2018250233 (A1) 2018-09-06
  4. Coated tablets and the production thereofPublication info: TW201811316 (A) 2018-04-01
  5. USE OF SILICON OXIDE-BASED MATERIAL FOR THE MODIFIED RELEASE OF BIOLOGICALLY ACTIVE AGENTSPublication info: JP2018090621 (A) 2018-06-14
  6. FORMULATION HAVING CONTROLLED, DELAYED ACTIVE-INGREDIENT RELEASEPublication info: KR20180052126 (A) 2018-05-17
  7. MAGNESIUM HYDROXIDE CARBONATE AS EXCIPIENT IN PHARMACEUTICAL PREPARATIONS, HAVING IMPROVED RELEASE OF ACTIVE INGREDIENTPublication info: BR112015014739 (A2) 2017-07-11
  8. MAGNESIUM HYDROXIDE CARBONATE AS CARRIER MATERIAL IN ACTIVE INGREDIENT-CONTAINING PREPARATIONSPublication info: BR112015005621 (A2) 2017-07-04
  9. PROCESS FOR IMPROVING THE DISSOLUTION BEHAVIOUR OF COMPONENTS IN AQUEOUS SOLUTIONSPublication info: WO2018019812 (A1) 2018-02-01
  10. PROCESS FOR PRODUCING INORGANIC PARTICULATE MATERIALPublication info: HK1222165 (A1) 2017-06-23
  11. PARTICLE SIZE AND DISTRIBUTION OF POLYMER FOR MELT EXTRUSION APPLICATIONPublication info: WO2017194578 (A1) 2017-11-16
  12. USE OF AMINO SUGAR AS PLASTICIZERPublication info: WO2017194577 (A1) 2017-11-16
  13. HOT MELT EXTRUSION COMPOSITION USING DIRECT COMPRESSIBLE EXCIPIENT AS PLASTICIZERPublication info: WO2017194576 (A1) 2017-11-16
  14. Production of monolithic separating columnsPublication info: ES2593478 (T3) 2016-12-09
  15. Immobilised imidazoles and ruthenium catalystsPublication info: TW200523027 (A) 2005-07-16
  16. GEL MOULD FOR THE PRODUCTION OF SHAPED BODIESPublication info: ES2425346 (T3) 2013-10-14
  17. SEPARATING AGENT FOR OPTICAL ISOMERS AND SEPARATION COLUMN FOR OPTICAL ISOMERSPublication info: US2011094955 (A1) 2011-04-28
  18. Microplate for processing samplesPublication info: AT501429 (T) 2011-03-15
  19. USE OF MONOLITHIC SORBENTS FOR PREPARATIVE CHROMATOGRAPHIC SEPARATIONPublication info: AT478732 (T) 2010-09-15
  20. CHEMICALLY MODIFIED POROUS MATERIAL WITH ELECTRONEUTRAL HYDROPHILIC OUTER SURFACEPublication info: JP2010014716 (A) 2010-01-21
  21. COLUMNA DE CROMATOGRAFIA, QUE CONTIENE SORBENTES MONOLITICOS CONREVESTIMIENTO DE MATERIAL SINTETICO REFORZADO CON FIBRAS Y SU EMPLEO.Publication info: ES2322934 (T3) 2009-07-02
  22. Device and Method for Coupling Capillary Separation Methods and Mass SpectrometryPublication info: US2008315083 (A1) 2008-12-25
  23. Surface Modification Of Solid Support MaterialsPublication info: US2008193651 (A1) 2008-08-14
  24. SEPARATING MATERIALS FOR CHROMATOGRAPHY COMPRISING CYCLODEXTRIN CHEMICALLY BONDED TO A SUPPORT VIA A CARBAMIC ACID GROUPPublication info: US5104547 (A) 1992-04-14
  25. Open Tubular Capillaries Having a Connecting LayerPublication info: US2007267348 (A1) 2007-11-22
  26. Inorganic monolithic mouldings coated with organic polymersPublication info: US2006099402 (A1) 2006-05-11
  27. Restricted access material for SPMEPublication info: US2004191537 (A1) 2004-09-30
  28. Modified chromatographic support materialsPublication info: US6074555 (A) 2000-06-13
  29. Catalyst support, production and use thereof in the polymerization of olefinsPublication info: US2004014917 (A1) 2004-01-22
  30. Method for producing monolithic chromatography columnsPublication info: US2003155676 (A1) 2003-08-21
  31. Polymerisable polyamide derivativesPublication info: US6149994 (A) 2000-11-21
  32. Monolithic frit for a capillary columnPublication info: US2003021730 (A1) 2003-01-30
  33. Device for processing samples, use of the device, and method for producing the devicePublication info: US2002182114 (A1) 2002-12-05
  34. Use of a reversed-phase support material in capillary electrochromatographyPublication info: US2005217994 (A1) 2005-10-06
  35. ENVOLTURAS PARA SORBENTES MONOLITICOS.Publication info: ES2212320 (T3) 2004-07-16
  36. GRADIENT ELUSION METHODPublication info: EP0989896 (A1) 2000-04-05
  37. CHIRAL NON-PARTICULATE SORBENTSPublication info: EP0912242 (A1) 1999-05-06
  38. USE OF NON-PARTICULATE SORBENTS FOR SIMULATED MOVING BED SEPARATING METHODSPublication info: EP0921847 (A1) 1999-06-16
  39. PRODUCTION OF MONOLITHIC SEPARATING COLUMNSPublication info: EP1843155 (A1) 2007-10-10
  40. Preparation of monolithic separation columnsPublication info: EP1843154 (A1) 2007-10-10
  41. POROUS ORGANIC POLYMER SHAPED BODIESPublication info: EP1218100 (A1) 2002-07-03
  42. FIBER-REINFORCED PLASTIC TUBES FOR HPLCPublication info: EP1194201 (A1) 2002-04-10
  43. END PIECE FOR MONOLITHIC CHROMATOGRAPHY COLUMNSPublication info: EP1154826 (A1) 2001-11-21
  44. DENDRIMERIC GRAFT POLYMERSPublication info: WO9631549 (A1) 1996-10-10
  45. Preparative chromatographic separation, e.g. of enantiomersPublication info: DE19801575 (A1) 1999-07-22
  46. Chiral sorbent for rapid enantiomer separationPublication info: DE19726152 (A1) 1998-12-24
  47. Simulated moving bed separationPublication info: DE19726151 (A1) 1998-12-24
  48. Polymerisable polyamide derivatives containing double bondsPublication info: DE19629206 (A1) 1998-01-22
  49. Dendrimeric graft copolymersPublication info: DE19512704 (A1) 1996-10-10
  50. Production of amorphous catalyst support, used for olefin polymerization catalysts, involves forming gels of aluminum (hydroxide and silicon (hydroxide, mixing, homogenizing and spray dryingPublication info: DE10052600 (A1) 2002-04-25
  51. METHOD AND SYSTEM FOR METHOD OPTIMISATION IN CHROMATOGRAPHYPublication info: DE10049079 (A1) 2002-04-18
  52. Capillary column containing sorbent particles is sealed at least at one end by a monolithic frit of an organic or inorganic materialPublication info: DE10028572 (A1) 2001-12-20
  53. Capillary column containing sorbent particles is sealed at least at one end by a monolithic frit of an organic or inorganic materialPublication info: DE10004637 (A1) 2001-08-09

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