Roland Kellner

The best ideas then come to my mind when travelling home.

Perspective

Proteins are major players in nature; understanding the roles and activities of these complex molecules is a fascinating task, especially in the context of healthcare. For me as analytical chemist it became an ongoing challenge to be part of this endeavor. There is no simple routine but always a colorful spectrum of projects and samples: small neuropeptides or large antibodies, highest sensitivity or large scale production, unknown target identification or reproducible quality assurance. Furthermore, protein analytics is very technology driven. Namely, mass spectrometry is a powerful but demanding technology that became a method of choice in the drug discovery work-flow.

Biotherapeutics are of increasing importance for patients, and therefore for our R&D efforts. Molecular characterisation of function of the target molecules and verification of their quality is mandatory for all steps in the drug discovery work-flow. In this respect, I am convinced that protein analytics can significantly contribute to our company´s future activities.

Analytical tasks in early drug discovery are never the same. Either a new target idea needs verification, a promising candidate needs optimization, or an improved technology needs adaptation. I really enjoy listening to colleagues on international meetings, learning from their approaches and how they tackled analytical issues. The best ideas then come to my mind when travelling home.

The best ideas then come to my mind when travelling home.

Roland Kellner

Head of Protein Analytics

Profile

Joined Merck KGaA, Darmstadt, Germany: 1997

Key research fields and topics:

  • Antibody-drug-conjugates for Oncology and ImmunOncology
  • Discovery Technologies: Application of mass spectrometry and chromatography for determination of peptides and proteins 

Prizes and awards:

  • Preis der Deutschen Gesellschaft für Massenspektrometrie "Massenspektrometrie in den Biowissenschaften" 2012

CV & Scientific activities

CV

CV

1979 - 1989
Chemistry, University of Tübingen
Doctoral Thesis: Lantibiotica – ribosomal synthetisierte Polypeptidantibiotika.
Ph.D. supervisor: Prof. G. Jung.
1989 - 1990
Protein Product Specialist, Applied Biosystems, Germany/USA.
1990 - 1994
Head of Protein Core Facility, EMBL, Heidelberg.
1994 - 1997
Postdoctoral lecturer C1. University of Mainz.
Supervisor: Prof. W. Müller-Esterl.
since 1997
Head of Protein Analytics. Merck KGaA, Darmstadt, Germany

Scientific activities

Scientific activities

1994 – 2016
Arbeitstagung Proteinchemie. (23 annual conferences)
Organisation: Kellner R, Lottspeich F, Meyer HE.
since 2002
German Society for Proteome Research, DGPF.
Board member.
2018
1st Merck KGaA, Darmstadt, Germany BioForum MassSpec. Rome,
24-26 Sep 2018.
Organisation: Haas T, Pötzsch S, Kellner R..

References

Book / book chapters

  • Kellner R, Lottspeich F, Meyer H. Microcharacterization of Proteins. Wiley-VCH, 1999, 2nd ed.
  • Kellner R. Chromatographische Trennmethoden. In: Bioanalytik, Lottspeich F, Zorbas H. Spektrum Verlag, 1998.

Peer-reviewed journals

  •  Dickgiesser S, Deweid L, Kellner R, Kolmar H, Rasche N. Site-specific antibody-drug conjugation using microbial transglutaminase. Meth Mol Biol 2018. In print.
  • Dickgiesser S, Kellner R, Kolmar H, Rasche N. Site-specific conjugation of thiol-reactive cytotoxic agents to non-native cysteines of engineered monoclonal antibodies. Meth Mol Biol 2018. In print.
  1. Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, et al. Approaching clinical proteomics: Current state and future fields of application in fluid proteomics. Clin Chem Lab Med. 2009;47(6).
  2. Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, et al. Approaching Clinical Proteomics: Current State and Future Fields of Application in Cellular Proteomics. Cytom Part A. 2009;75(10).
  3. Arand M, Müller F, Mecky A, Hinz W, Urban P, Pompon D, et al. Catalytic triad of microsomal epoxide hydrolase: Replacement of Glu404 with Asp leads to a strongly increased turnover rate. Biochem J. 1999;337(1).
  4. Bahr U, Karas M, Kellner R. Differentiation of lysine/glutamine in peptide sequence analysis by electrospray ionization sequential mass spectrometry coupled with a quadrupole ion trap. Rapid Commun Mass Spectrom. 1998;12(19).
  5. Beisswanger R, Corbeil D, Vannier C, Thiele C, Dohrmann U, Kellner R, et al. Existence of distinct tyrosylprotein sulfotransferase genes: Molecular characterization of tyrosylprotein sulfotransferase-2. Proc Natl Acad Sci U S A. 1998;95(19).
  6. Christoforidis S, Papamarcaki T, Galaris D, Kellner R, Tsolas O. Purification and Properties of Human Placental ATP Diphosphohydrolase. Eur J Biochem. 1995;234(1).
  7. Emans N, Gorvel J-P, Walter C, Gerke V, Kellner R, Griffiths G, et al. Annexin II is a major component of fusogenic endosomal vesicles. J Cell Biol. 1993;120(6).
  8. Feldhoff A, Wetzel T, Peters D, Kellner R, Krczal G. Characterization of petunia flower mottle virus (PetFMV), a new potyvirus infecting Petunia x hybrida. Arch Virol. 1998;143(3).
  9. Fiedler K, Kellner R, Simons K. Mapping the protein composition of trans-Golgi network (TGN)-derived carrier vesicles from polarized MDCK cells. Electrophoresis. 1997;18(14).
  10. Fiedler K, Parton RG, Kellner R, Etzold T, Simons K. VIP36, a novel component of glycolipid rafts and exocytic carrier vesicles in epithelial cells. EMBO J. 1994;13(7).
  11. Freund J, Kellner R, Houthaeve T, Kalbitzer HR. Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1. Eur J Biochem. 1994;221(2).
  12. Freund J, Kellner R, Konvalinka J, Wolber V, Kräusslich H ‐G., Kalbitzer HR. A possible regulation of negative factor (Nef) activity of human immunodeficiency virus type 1 by the viral protease. Eur J Biochem. 1994;223(2).
  13. Frick I-M, Axcrona K, Härdig Y, Tapper H, Gustafsson L, Kellner R, et al. Uptake and intracellular transportation of a bacterial surface protein in lymphoid cells. Mol Microbiol. 2002;44(4).
  14. Friderich G, Klumpp S, Russell CB, Hinrichsen RD, Kellner R, Schultz JE. Purification, characterization and structure of protein phosphatase 1 from the cilia of Paramecium tetraurelia. Eur J Biochem. 1992;209(1).
  15. Frins S, Bönigk W, Müller F, Kellner R, Koch K-W. Functional characterization of a guanylyl cyclase-activating protein from vertebrate rods: Cloning, heterologous expression, and localization. J Biol Chem. 1996;271(14).
  16. Gäde G, Grandcolas P, Kellner R. Structural data on hypertrehalosaemic neuropeptides from Cryptocercus punctulatus and Therea petiveriana: How do they fit into the phylogeny of cockroaches? Proc R Soc B Biol Sci. 1997;264(1382).
  17. Gäde G, Janssens MP-E, Kellner R. A novel peptide in the AKH/RPCH family isolated from the corpora cardiaca of the Emperor dragonfly, Anax imperator. Peptides. 1994;15(1).
  18. Gäde G, Kellner R. Dragonfly Erythemis simplicicollis contains a novel adipokinetic neuropeptide. Arch Insect Biochem Physiol. 1999;40(2).
  19. Gäde G, Kellner R. Isolation and primary structure of a novel adipokinetic peptide from the pyrgomorphid grasshopper, Phymateus leprosus. Regul Pept. 1995;57(3).
  20. Gäde G, Kellner R. Primary structures of the hypertrehalosemic peptides from corpora cardiaca of the primitive cockroach Polyphaga aegyptiaca. Gen Comp Endocrinol. 1992;86(1).
  21. Gäde G, Kellner R. The metabolic neuropeptides of the corpus cardiacum from the potato beetle and the American cockroach are identical. Peptides. 1989;10(6).
  22. Gäde G, Kellner R, Rinehart KL. Pyrgomorphid grasshoppers of the genus Phymateus contain species-specific decapeptides of the AKH/RPCH family regulating lipid-mobilization during flight. Physiol Entomol. 1996;21(3).
  23. Gäde G, Kellner R, Rinehart KL, Proefke ML. A tryptophan-substituted member of the AKH/RPCH family isolated from a stick insect corpus cardiacum. Biochem Biophys Res Commun. 1992;189(3).
  24. Gäde G, Lee MJ, Goldsworthy GJ, Kellner R. Potencies of naturally-occurring AKH/RPCH peptides in Locusta migratoria in the acetate uptake assay in vitro and comparison with their potencies in the lipid mobilisation assay in vivo. Acta Biol Hung. 2000;51(2–4).
  25. Gäde G, Lopata A, Kellner R, Rinehart KL. Primary Structures of Neuropeptides Isolated from the Corpora Cardiaca of Various Cetonid Beetle Species Determined by Pulsed-Liquid Phase Sequencing and Tandem Fast Atom Bombardment Mass Spectrometry. Biol Chem Hoppe Seyler. 1992;373(1).
  26. Gäde G, Wilps H, Kellner R. Isolation and structure of a novel charged member of the red-pigment-concentrating hormone-adipokinetic hormone family of peptides isolated from the corpora cardiaca of the blowfly Phormia terraenovae (Diptera). Biochem J. 1990;269(2).
  27. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein. J Mol Biol. 1999;289(1).
  28. Harder T, Kellner R, Parton RG, Gruenberg J. Specific release of membrane-bound annexin II and cortical cytoskeletal elements by sequestration of membrane cholesterol. Mol Biol Cell. 1997;8(3).
  29. Hausinger A, Volknandt W, Kretzschmar S, Kellner R, Zimmermann H. Two synpatic vesicle proteins of 25 kDa: A comparison of the molecular properties and tissue distribution of svp25 and o-rab3. Neurochem Int. 1996;28(3).
  30. Herrmann C, Kellner R, Volknandt W. Major vault protein of electric ray is a phosphoprotein. Neurochem Res. 1998;23(1).
  31. Herwald H, Dedio J, Kellner R, Loos M, Müller-Esterl W. Isolation and characterization of the kininogen-binding protein p33 from endothelial cells: Identity with the gClq receptor. J Biol Chem. 1996;271(22).
  32. Hörner T, Ungermann V, Zähner H, Fiedler H-P, Utz R, Kellner R, et al. Comparative studies on the fermentative production of lantibiotics by staphylococci. Appl Microbiol Biotechnol. 1990;32(5).
  33. Hörner T, Zähner H, Kellner R, Jung G. Fermentation and isolation of epidermin, a lanthionine containing polypeptide antibiotic from Staphylococcus epidermidis. Appl Microbiol Biotechnol. 1989;30(3).
  34. Janssens MP-E, Kellner R, Gade G. A novel adipokinetic octapeptide found in the damselflies Pseudagrion inconspicuum and Ischnura senegalensis. Biochem J. 1994;302(2).
  35. Kaletta C, Entian K-D, Kellner R, Jung G, Reis M, Sahl H-G. Pep5, a new lantibiotic: structural gene isolation and prepeptide sequence. Arch Microbiol. 1989;152(1).
  36. Kellner R. Proteomics. Concepts and perspectives. Fresenius J Anal Chem. 2000;366(6–7).
  37. Kellner R, Houthaeve T, Kurzchalia T, Dupree P, Simons K. Internal fragmentation of proteins in polyacrylamide matrices for microsequencing. J Protein Chem. 1992;11(4).
  38. Kellner R, Jung G, Hörner T, Zähner H, Schnell N, Entian K ‐D., et al. Gallidermin: a new lanthionine‐containing polypeptide antibiotic. Eur J Biochem. 1988;177(1).
  39. Kellner R, Jung G, Josten M, Kaletta C, Entian K ‐D., Sahl H ‐G. Pep5: Structure Elucidation of a Large Lantibiotic. Angew Chemie Int Ed English. 1989;28(5).
  40. Kellner R, Lichtenfels R, Atkins D, Bukur J, Ackermann A, Beck J, et al. Targeting of tumor associated antigens in renal cell carcinoma using proteome-based analysis and their clinical significance. Proteomics. 2002;2(12).
  41. Kellner R, Orth T, Mayet W-J. Characterization of target antigens from anti-neutrophil cytoplasmic antibodies in autoimmune hepatitis type-I. Electrophoresis. 1997;18(3–4).
  42. Kellner R, Talbo G, Houthaeve T, Mann M. Edman degradation and MALDI sequencing enables N- and C-terminal sequence analysis of peptides. Vol. 6, Techniques in Protein Chemistry. 1995. 47-54 p.
  43. Kessler H, Steuernagel S, Will M, Jung G, Kellner R, Gillessen D, et al. The Structure of the Polycyclic Nonadecapeptide Ro 09‐0198. Helv Chim Acta. 1988;71(8).
  44. Kleemann G, Kellner R, Poralla K. Purification and properties of the squalene-hopene cyclase from Rhodopseudomonas palustris, a purple non-sulfur bacterium producing hopanoids and tetrahymanol. Biochim Biophys Acta (BBA)/Lipids Lipid Metab. 1994;1210(3):317–20.
  45. Klumpp S, Hanke C, Donella-Deana A, Beyer A, Kellner R, Pinna LA, et al. A membrane-bound protein phosphatase type 2C from Paramecium tetraurelia. Purification, characterization, and cloning. J Biol Chem. 1994;269(52).
  46. Klumpp S, Hermesmeier J, Selke D, Bechmann G, Van den Brulle J, Weidner G, et al. Erratum: Protein histidine phosphatase: A novel enzyme with potency for neuronal signaling (Journal of Cerebral Blood Flow and Metabolism (December 2002) (1420-1424)). J Cereb Blood Flow Metab. 2003;23(2).
  47. Klumpp S, Hermesmeier J, Selke D, Baumeister R, Kellner R, Krieglstein J. Protein histidine phosphatase: A novel enzyme with potency for neuronal signaling. J Cereb Blood Flow Metab. 2002;22(12):1420–4.
  48. Kluwe L, Maeda K, Miegel A, Fujita-Becker S, Maéda Y, Talbo G, et al. Rabbit skeletal muscle αα-tropomyosin expressed in baculovirus-infected insect cells possesses the authentic N-terminus structure and functions. J Muscle Res Cell Motil. 1995;16(2).
  49. Koch K ‐W., Stecher P, Kellner R. Bovine retinal rod guanyl cyclase represents a new N‐glycosylated subtype of membrane‐bound guanyl cyclases. Eur J Biochem. 1994;222(2).
  50. Kohlstedt K, Kellner R, Busse R, Fleming I. Signaling via the angiotensin-converting enzyme results in the phosphorylation of the nonmuscle myosin heavy chain IIA. Mol Pharmacol. 2006;69(1).
  51. Köllisch GV, Lorenz MW, Kellner R, Verhaert PD, Hoffmann KH. Structure elucidation and biological activity of an unusual adipokinetic hormone from corpora cardiaca of the butterfly, Vanessa cardui. Eur J Biochem. 2000;267(17).
  52. Köllisch GV, Verhaert PD, Lorenz MW, Kellner R, Gäde G, Hoffmann KH. Structure elucidation of Mas-AKH as the major adipokinetic hormone in the butterfly Vanessa cardui (Lepidoptera: Nymphalidae). Eur J Entomol. 1999;96(3).
  53. Körschen HG, Beyermann M, Müller F, Heck M, Vantler M, Koch K-W, et al. Interaction of glutamic-acid-rich proteins with the cGMP signalling pathway in rod photoreceptors. Nature. 1999;400(6746).
  54. Kurzchalia TV, Dupree P, Parton RG, Kellner R, Virta H, Lehnert M, et al. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi- network-derived transport vesicles. J Cell Biol. 1992;118(5).
  55. Kurzchalia TV, Gorvel J-P, Dupree P, Parton R, Kellner R, Houthaeve T, et al. Interactions of rab5 with cytosolic proteins. J Biol Chem. 1992;267(26).
  56. Lesieur C, Frutiger S, Hughes G, Kellner R, Pattus F, Van Der Goott FG. Increased stability upon heptamerization of the pore-forming toxin aerolysin. J Biol Chem. 1999;274(51).
  57. Lichtenfels R, Ackermann A, Kellner R, Seliger B. Mapping and expression pattern analysis of key components of the major histocompatibility complex class I antigen processing and presentation pathway in a representative human renal cell carcinoma cell line. Electrophoresis. 2001;22(9).
  58. Lichtenfels R, Kellner R, Atkins D, Bukur J, Ackermann A, Beck J, et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta - Proteins Proteomics. 2003;1646(1–2).
  59. Lichtenfels R, Kellner R, Bukur J, Beck J, Brenner W, Ackermann A, et al. Heat shock protein expression and anti-heat shock protein reactivity in renal cell carcinoma. Proteomics. 2002;2(5).
  60. Liebrich W, Kellner R, Gäde G. Isolation and primary structures of neuropeptides of the AKH RPCH family from various termite species. Peptides. 1995;16(4).
  61. Lorenz MW, Kellner R, Hoffmann KH. Allatostatins in Gryllus bimaculatus (Ensifera: Gryllidae): New structures and physiological properties. Eur J Entomol. 1999;96(3).
  62. Lorenz MW, Kellner R, Hoffmann KH. A family of neuropeptides that inhibit juvenile hormone biosynthesis in the cricket, Gryllus bimaculatus. J Biol Chem. 1995;270(36).
  63. Lorenz MW, Kellner R, Hoffmann KH. Identification of two allatostatins from the cricket, Gryllus bimaculatus de Geer (Ensifera, Gryllidae): additional members of a family of neuropeptides inhibiting juvenile hormone biosynthesis. Regul Pept. 1995;57(3).
  64. Lorenz MW, Kellner R, Hoffmann KH, Gäde G. Identification of multiple peptides homologous to cockroach and cricket allatostatins in the stick insect Carausius morosus. Insect Biochem Mol Biol. 2000;30(8–9).
  65. Lorenz MW, Kellner R, Temnow K, Woodring J. Identification of the adipokinetic hormone of the large milkweed bug Oncopeltus fasciatus. Physiol Entomol. 2009;34(2).
  66. Lorenz MW, Kellner R, Völkl W, Hoffmann KH, Woodring J. A comparative study on hypertrehalosaemic hormones in the hymenoptera: Sequence determination, physiological actions and biological significance. J Insect Physiol. 2001;47(6).
  67. Lorenz MW, Kellner R, Woodring J, Hoffmann KH, Gäde G. Hypertrehalosaemic peptides in the honeybee (Apis mellifera): Purification, identification and function. J Insect Physiol. 1999;45(7).
  68. Munte CE, Gäde G, Domogalla B, Kremer W, Kellner R, Kalbitzer HR. C-mannosylation in the hypertrehalosaemic hormone from the stick insect Carausius morosus. FEBS J. 2008;275(6).
  69. Noll S, Reyelt J, Rysiok T, Kellner R, Güssow D, Jäkel S, et al. Heterologous protein expression: Targeted optimization of Escherichia coli BL21 (DE3). BioSpektrum. 2013;19(2).
  70. Ochs D, Tappe CH, Gärtner P, Kellner R, Poralla K. Properties of purified squalene‐hopene cyclase from Bacillus acidocaldarius. Eur J Biochem. 1990;194(1).
  71. Orth T, Gerken G, Kellner R, Meyer Zum Büschenfelde K-H, Mayet W-J. Actin is a target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune hepatitis type-1. J Hepatol. 1997;26(1).
  72. Orth T, Kellner R, Diekmann O, Faust J, Meyer Zum Büschenfelde K-H, Mayet W-J. Identification and characterization of autoantibodies against catalase and α-enolase in patients with primary sclerosing cholangitis. Clin Exp Immunol. 1998;112(3).
  73. Predel R, Brandt W, Kellner R, Rapus J, Nachman RJ, Gade G. Post-translational modifications of the insect sulfakinins: Sulfation, pyroglutamate-formation and O-methylation of glutamic acid. Eur J Biochem. 1999;263(2).
  74. Predel R, Kellner R, Baggerman G, Steinmetzer T, Schoofs L. Identification of novel periviscerokinins from single neurohaemal release sites in insects. MS/MS fragmentation complemented by Edman degradation. Eur J Biochem. 2000;267(12).
  75. Predel R, Kellner R, Gäde G. Myotropic neuropeptides from the retrocerebral complex of the stick insect, Carausius morosus (Phasmatodea: Lonchodidae). Eur J Entomol. 1999;96(3).
  76. Predel R, Kellner R, Kaufmann R, Penzlin H, Gäde G. Isolation and structural elucidation of two pyrokinins from the retrocerebral complex of the American cockroach. Peptides. 1997;18(4).
  77. Predel R, Kellner R, Nachman RJ, Holman GM, Rapus J, Gäde G. Differential distribution of pyrokinin-isoforms in cerebral and abdominal neurohemal organs of the American cockroach. Insect Biochem Mol Biol. 1999;29(2).
  78. Predel R, Kellner R, Rapus J, Gäde G. Allatostatins from the retrocerebral complex and antennal pulsatile organ of the American cockroach: Structural elucidation aided by matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Regul Pept. 1999;82(1–3).
  79. Predel R, Kellner R, Rapus J, Penzlin H, Gáde G. Isolation and structural elucidation of eight kinins from the retrocerebral complex of the American cockroach, Periplaneta americana. Regul Pept. 1997;71(3).
  80. Recktenwald CV, Kellner R, Lichtenfels R, Seliger B. Altered detoxification status and increased resistance to oxidative stress by K-Ras transformation. Cancer Res. 2008;68(24).
  81. Recktenwald CV, Mendler S, Lichtenfels R, Kellner R, Seliger B. Influence of Ki-ras-driven oncogenic transformation on the protein network of murine fibroblasts. Proteomics. 2007;7(3).
  82. Ringdahl U, Svensson M, Wistedt AC, Renné T, Kellner R, Müller-Esterl W, et al. Molecular co-operation between protein PAM and streptokinase for plasmin acquisition by Streptococcus pyogenes. J Biol Chem. 1998;273(11).
  83. Rojo M, Budin N, Kellner R, Gruenberg J. Generation of proteoliposomes from subcellular fractions. Electrophoresis. 1997;18(14).
  84. Rojo M, Pepperkok R, Emery G, Kellner R, Stang E, Parton RG, et al. Involvement of the transmembrane protein p23 in biosynthetic protein transport. J Cell Biol. 1997;139(5).
  85. Schnell N, Entian K-D, Götz F, Hörner T, Kellner R, Jung G. Structural gene isolation and prepeptide sequence of gallidermin, a new lanthionine containing antibiotic. FEMS Microbiol Lett. 1989;58(2–3).
  86. Schnell N, Entian K-D, Schneider U, Gotz F, Kellner R, Jung G. Propeptide sequence of epidermin: A ribosomally synthesized peptide antibiotic. J Protein Chem. 1988;7(3).
  87. Schnell N, Entian K-D, Schneider U, Götz F, Zähner H, Kellner R, et al. Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings. Nature. 1988;333(6170).
  88. Schorr J, Kellner R, Fackler O, Freund J, Konvalinka J, Kienzle N, et al. Specific cleavage sites of Nef proteins from human immunodeficiency virus types 1 and 2 for the viral proteases. J Virol. 1996;70(12).
  89. Seliger B, Dressler SP, Wang E, Kellner R, Recktenwald CV, Lottspeich F, et al. Combined analysis of transcriptome and proteome data as a tool for the identification of candidate biomarkers in renal cell carcinoma. Proteomics. 2009;9(6).
  90. Seliger B, Kellner R. Biomarker Discovery in Renal Cell Carcinoma Applying Proteome-Based Studies in Combination with Serology. Proteomics in Drug Research. 2006.
  91. Seliger B, Kellner R. Design of proteome-based studies in combination with serology for the identification of biomarkers and novel targets. Proteomics. 2002;2(12).
  92. Seliger B, Lichtenfels R, Kellner R. Detection of renal cell carcinoma-associated markers via proteome- and other ’ome’-based analyses. Briefings Funct Genomics Proteomics. 2003;2(3).
  93. Seliger B, Menig M, Lichtenfels R, Atkins D, Bukur J, Halder TM, et al. Identification of markers for the selection of patients undergoing renal cell carcinoma-specific immunotherapy. Proteomics. 2003;3(6).
  94. Seliger B, Dressler SP, Lichtenfels R, Kellner R. Candidate biomarkers in renal cell carcinoma. Proteomics. 2007;7(24):4601–12.
  95. Siegert KJ, Kellner R, Gäde G. A third active AKH is present in the pyrgomorphid grasshoppers Phymateus morbillosus and Dictyophorus spumans. Insect Biochem Mol Biol. 2000;30(11).
  96. Straif D, Werz O, Kellner R, Bahr U, Steinhilber D. Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells. Biochem J. 2000;349(2).
  97. Tawfik AI, Kellner R, Hoffmann KH, Lorenz MW. Purification, characterisation and titre of the haemolymph juvenile hormone binding proteins from Schistocerca gregaria and Gryllus bimaculatus. J Insect Physiol. 2006;52(3).
  98. Wind M, Wegener A, Eisenmenger A, Kellner R, Lehmann WD. Sulfur as the key element for quantitative protein analysis by capillary liquid chromatography coupled to element mass spectrometry. Angew Chemie - Int Ed. 2003;42(29).
  99. Wind M, Wegener A, Kellner R, Lehmann WD. Analysis of CheA histidine phosphorylation and its influence on protein stability by high-resolution element and electrospray mass spectrometry. Anal Chem. 2005;77(7).
  100. Woodring J, Das S, Kellner R, Gäde G. The Sequence of Acheta Adipokinetic Hormone and the Variation in Corpus cardiacum Content and Hyperlipaemic Response with Age. Zeitschrift fur Naturforsch - Sect C J Biosci. 1990;45(11–12).

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