Romas Skudas

Moreover inspiration and motivation is pushed by companies strategy to find a balance between business driven and crazy science governed decisions.


Perspective

The greatest aspects of my work is the everyday dynamics and challenge that I am faced with as a manager and scientists. Demanding and very intelligent customers, newest technologies and variety of cultures round-up the picture that  makes me jump out of my bed every morning with passion to face the upcoming day. Moreover inspiration and motivation is pushed by companies strategy to find a balance between business driven and crazy science governed decisions.

Moreover inspiration and motivation is pushed by companies strategy to find a balance between business driven and crazy science governed decisions.

Romas Skudas

Senior Scientist/Lab Head, Process Solutions Chromatography R&D Group

Profile

Joined Merck KGaA, Darmstadt, Germany: 2009

Key research fields and topics:

  • Synthesis, characterization and modelling of separation materials and their use in biopharmaceutical molecule characterization
  • Development and integration of new technologies (e.g. continuous purification for the monoclonal antibody molecules)
  • Establishment of analytic methods (e.g. infrared spectroscopy for biomolecule quality control) 
  • Research on specialized purification methods increasing drug product efficacy (e.g. charge variant separation for monoclonal antibodies). 
  • Development of cation exchange supports for various biopharmaceutical molecule purification and custom solutions for the most challenging purification problems. 

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CV & Scientific activities

CV: Education

CV: Education

CV: Professional Career

CV: Professional Career

References

Publications:

Articles:

  1. LefeB. Lefevre, A. Galarneau, J. Iapichelly, C. Petitto, F. Di Renza, F. Fajula, Z. Bayram-Hahn, R. Skudas and K.K. Unger “Synthesis of large-pore mesostructured micelle-templated silicas as discrete spheres” Chem. Mater., 2005, 17; 601-607 (8.54 Impact factor);
  2. B.A. Grimes, R. Skudas, K.K. Unger and D. Lubda “Pore structural characterization of monolithic silica columns by Inverse Size Exclusion Chromatography” J. Chromatogr. A, 1144 (2007); 14-29 (4,61 Impact factor);
  3. R. Skudas, B.A. Grimes, E. Machtejevas, V. Kudirkaite, T.P. Hennessy, D. Lubda and K.K. Unger “Impact of pore structural parameters on column performance and resolution of reversed phase monolithic silica columns for peptides and proteins” J. Chromatogr. A, 1144 (2007) 72-84 (4.61 Impact factor);
  4. Z. Bayram-Hahn, B. Grimes, A. Lind, R. Skudas, K.K. Unger, A. Galarneau, J. Iapichaella, F. Fajula “Pore structural characteristics, size exclusion properties and column performance of two trasformed MCM-41 type derivatives” J. Sep Sci., 2007, 30, 3089-3103 (2.59 Impact factor);
  5. K.K. Unger, R. Skudas and M.M. Schulte “ Particle packed columns and monolithic columns in high-performance liquid chromatography – comparison and critical appraisal” J. Chromatogr. A, 1184 (2008) 393-415 (4.61 Impact factor);
  6. M. Thommes, R. Skudas, K.K. Unger and D. Lubda “Textural characterization of native and n-alkyl-bonded silica monoliths by mercury intrusion/extrusion, inverse size exclusion chromatography and nitrogen sorption” J. Chromatogr. A, 1191 (2008) 57-66 (Impact factor 4.61);
  7. R. Skudas, B.A. Grimes, M. Thommes and K.K. Unger “Flow-through pore characteristics of monolithic silicas and their impact on column performance in HPLC” J. Chromatogr. A, 1216 (2009) 2625-2636 (Impact factor 4.61);
  8. K.K. Unger, E. Machtejevas, R. Ditz and R. Skudas “Liquid chromatography – its development and key role in life science applications” Angew Chem Int Ed Engl. 2010 Mar 22; 49(13):2300-12. Review (11.34 Impact factor);
  9. J. Rouquerol, G. Baron, R. Denoyel, H. Giesche, J. Groen, P. Klobes, P. Levitz, A.V. Neimark, S. Rogby, R. Skudas, K. Sing, M. Thommes and K.K. Unger “Liquid intrusion and alternative methods for the characterization of macroporous materials (IUPAC Technical Report)” Pure Appl. Chem., Vol. 84, No. 1, pp. 107–136, 2012 (3.39 Impact factor);
  10. F. Capito, R. Skudas, H. Kolmar and B. Stanislawski “Host cell protein quantification by fourier transform mid infrared spectroscopy (FT-MIR)” Biotechnology and Bioengineering, 110(1), 252-259 (4.16 Impact factor);
  11. F. Capito, R. Skudas, B. Stanislawski, H. Kolmar “Matrix effects during monitoring of antibody and host cell proteins using attenuated total reflection spectroscopy” Biotechnology progress, 29(1), 265-274 (1.85 Impact factor);
  12. F. Capito, R. Skudas, B. Stanislawski, H. Kolmar “Polyelectrolyte-protein interaction at low ionic strength: required chain flexibility depending on protein average charge” Colloid and Polymer Science, 297(7), 1759-1769 (2.16 Impact factor);
  13. F. Capito, R. Skudas, H. Kolmar and C. Hunzinger “Mid-infrared spectroscopy-based antibody aggregate quantification in cell culture fluids” Biotechnology journal, 8(8) 912-917 (3.71 Impact factor);
  14. F. Capito, R. Skudas, B. Stanislawski, H. Kolmar “Customization of copolymers to optimize selectivity and yield in polymer.driven antibody purification processes” Biotechnol Prog. 2013 Nov-Dec 29(6), 1484-93 (1.85 Impact factor);
  15. F. Capito, H. Kolmar, B. Edelmann, R. Skudas “Feasibility of polyelectrolyte-driven Fab fragment separation” Biotechnol J. 2014 May 9(5), 698-701 (3.71 Impact factor);
  16. I. Strug C. Utzat, A. Cappione, S. Gutierrez, R. Amara, J.. Lento, F. Capito, R. Skudas, E. Chermokalskaya, T. Nadler “Development of a univariate membrane-based mid.infrared method for protein quantification and total lipid content analysis of biological samples” J. Anal. Methods in Chemistry, 2014 September (0.948 Impact factor);
  17. Capito F, Zimmer A, Skudas R. “Mid-infrared spectroscopy-based analysis of mammalian cell culture parameters” Biotechnol Prog. 2015 Mar-Apr;31(2):578-84. doi: 10.1002/btpr.2026 (1.85 Impact factor);

Book Chapters:

  • “Characterization of the Pore Structure of Monolithic Silicas” in Monolithic Silicas in Separation Science 2011, WILEY-VCH, Verlag GmbH & Co KGaA, Weinheim, Germany
  • “Stationary phases and Chromatographic systems” in Preparative Chromatography 2012, WILEY-VCH, Verlag GmbH & Co KGaA, Weinheim, Germany
  • “Applications and Limitations of FT-MIR for Monitoring Critical Process Parameters during Downstream Processing of Therapeutic Proteins” in Infrared Spectroscopy –Theory, Developments and Applications 2014, Nova Science Publishers, New York, USA

Conferences:

Podium presentations:

  • MSS 2006, Portoroz – “The impact of pore structural parameters and skeleton domain size on the performance of monolithic silica columns”;
  • ISPPP 2007, Orlando – “Particle packed columns and monolithic columns in HPLC – a comparison and critical appraisal”;
  • HPLC 2008, Baltimore – “Comprehensive analysis of the macropore structure of silica monoliths as rods and fused silica capillaries and its impact to column performance”;
  • MSS 2008, Portoroz – “Determination of flow-through pore characteristic parameters of silica monolithic columns and their influence on the chromatographic separation performance”;
  • World Biopharm Forum 2010, Cambridge – “Recent advances in tentacle technology for biochromatography resins”;
  • SPICA 2012, Brussels – “Economic continuous chromatography case analysis”;
  • Bioproduction 2012, Berlin – “Economic continuous chromatography case analysis in three different application modes”;
  • Webinar 2013, - “How to increase productivity with Continuous Chromatography”;
  • EuroTides 2013, Prag – “Economic continuous reversed phase mode chromatography”;
  • AsiaTides 2014, Tokyo – “Economic continuous reversed phase mode chromatography”;
  • Webinar 2016 - “Robust flow through antibody polishing technology”
  • PREP 2016, Philadephia, USA – “Flow through chromatography and adsorptive depth filtration for continuous bioprocessing applications – case studies”
  • ISPPP 2016, Salzburg, Austria – “What is the most efficient ProteinA resin and why?”Advances in Purification technologies 2017, Boston – “Use of Activated Carbon as an Adsorbent in the polishing step”
  • IBC 2017, Shanghai – “Process Development for Insulin Purification – from Capturing to Filtration”
  • SPICA 2018, Darmstadt – “A new cation exchange resin designed for the removal of monoclonal antibody aggregates using flow-through frontal chromatography”
  • Webinar 2018 – “Custom Affinity Chromatography for Vaccine Purification: A new PD paradigm”

Invited podium presentations:

  • HPLC 2007, Ghent - “Particle packed columns and monolithic columns in HPLC – a comparison and critical appraisal”
  • Bioproduction 2014, Barcelona – “Robust flow through antibody polishing technology – case studies”
  • AAPS 2014, San Diego- “Economic continuous chromatography evaluation”
  • Biologics Congress 2015, Berlin – “Innovative Protein Analytics to Speed up Bioprocess Development”
  • Dowstream Processing, Claustal 2016 - “Fundaments of Biochromatography” 

Organized Conference meetings:

  • International Meeting on Separation Science, Johannes Gutenberg University, September 2005;
  • Material Science & Technology, University of Evora, Evora, Portugal, March 2006

Patents

  1. “Method and apparatus for chromatographic purification” EP2578286 2011-10-04;
  2. “Chromatography method” EP2656892 2012-04-23;
  3. “Chromatography method” US2013280788 2013-03-26;
  4. “Method and apparatus for chromatographic purification” WO2013050104 2012-09-15;
  5. “IR analysis of protein aggregates” WO2014154331 2014-03-13
  6. “Removal of fragments from the sample containing a target protein using activated carbon” WO2015005960 2014-04-04
  7. “Robust antibody purification” WO2015131976 2015-02-15
  8. “Activated Carbon for the removal of leachables and/or extractables” WO2016070957 2012-05-16
  9. “Target molecule capture from crude solutions” WO16096071  2016-06-23

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