Sal Giglia

Working with a great team in Bioprocessing R&D to help develop new products and technologies in pursuit of this vision is both inspiring and rewarding.


Perspective

As a leader in life science, a stated mission of our company is to solve the toughest problems in life science by collaborating with the global scientific community, to accelerate access to better health for people everywhere. Working with a great team in Bioprocessing R&D to help develop new products and technologies in pursuit of this vision is both inspiring and rewarding.  In such a challenging environment, there will inevitably be obstacles along the way, but when success is achieved it means that we have made another step forward towards fulfilling our vision. Being able to generate new scientific understandings and insights that lead to innovative solutions, and sharing these with our customers, including through our numerous partnerships and thought leadership activities, is greatly inspirational.  The culture of curiosity here at Merck KGaA, Darmstadt, Germany facilitates the creation of new ideas and the support that our company provides helps turn those ideas into practical solutions.  The present is exciting, and the future seems only brighter.

Working with a great team in Bioprocessing R&D to help develop new products and technologies in pursuit of this vision is both inspiring and rewarding.

Sal Giglia

Head of Applications group, Bioprocessing Filtration R&D

Profile

Joined Merck KGaA, Darmstadt, Germany: 2004

Key research fields and topics:

  • Development of new filters and filtration processes
  • Filtration applications in bioprocessing
  • Theoretical and practical foundations of filtration mechanisms in bioprocessing

Prizes and awards:

  • Millipore Chairman's award as a key contributor to the development of the Viresolve Pro virus filter
  • Praxair (previous employer) Chairman's award for the development of membranes for gas purification

CV & Scientific activities

CV: Education

CV: Education

BS in chemical engineering from Tufts University 
MS in chemical engineering from the University of Massachusetts

References

Publications:

  1. Fallahianbijan, Fatemeh, Sal Giglia, Christina Carbrello, David Bell, and Andrew L. Zydney. "Impact of Protein Fouling on Nanoparticle Capture within the Viresolve® Pro and Viresolve® NFP Virus Removal Membranes." Biotechnology and bioengineering (2019).
  2. Fallahianbijan, Fatemeh, Sal Giglia, Christina Carbrello, and Andrew L. Zydney. "Quantitative analysis of internal flow distribution and pore interconnectivity within asymmetric virus filtration membranes." Journal of Membrane Science (2019): 117578.
  3. Nazem-Bokaee, Hadi, Fatemeh Fallahianbijan, Dayue Chen, Sean Michael O'Donnell, Christina Carbrello, Sal Giglia, David Bell, and Andrew L. Zydney. "Probing pore structure of virus filters using scanning electron microscopy with gold nanoparticles." Journal of membrane science 552 (2018): 144-152.
  4. Fallahianbijan, Fatemeh, Sal Giglia, Christina Carbrello, and Andrew L. Zydney. "Use of fluorescently-labeled nanoparticles to study pore morphology and virus capture in virus filtration membranes." Journal of membrane science 536 (2017): 52-58.
  5. Giglia, Sal, Songhua Liu, and Ryan Sylvia. "Scaling Considerations to Maximize the High-Area Advantage." BioProcess International 15 (2017): 5.
  6. Giglia, Sal, John Caulmare, David Nhiem, and David Porreca. "Air-water binary gas integrity test for sterilizing and virus filters." PDA journal of pharmaceutical science and technology 70, no. 6 (2016): 577-590.
  7. Giglia, Sal, David Bohonak, Patricia Greenhalgh, and Anne Leahy. "Measurement of pore size distribution and prediction of membrane filter virus retention using liquid–liquid porometry." Journal of membrane science 476 (2015): 399-409.
  8. Rich, David, Mark Blanchard, Salvatore Giglia, Greg Straeffer, Amy Cazeault, Shannon Cleveland, Rebecca Bartkus, and Matthew Desmarais. "Engineering Practices During Manufacturing Process Development for New Products." Pharm Eng 33 (2013).
  9. Giglia, Sal, and Greg Straeffer. "Combined mechanism fouling model and method for optimization of series microfiltration performance." Journal of membrane science 417 (2012): 144-153.
  10. Giglia, Sal, and Mani Krishnan. "New binary gas integrity test improves membrane quality assurance." BioPharm International 24, no. 4 (2011): 24-28.
  11. Sal Giglia, and Laurelle Sciola. "TEST, DON'T GUESS." BioProcess International 9, no. 9 (2011): 58-62.
  12. Giglia, Sal, Kevin Rautio, Greg Kazan, Kari Backes, Mark Blanchard, and John Caulmare. "Improving the accuracy of scaling from discs to cartridges for dead end microfiltration of biological fluids." Journal of Membrane Science 365, no. 1-2 (2010): 347-355.
  13. Giglia, Sal, and Mani Krishnan. "High sensitivity binary gas integrity test for membrane filters." Journal of Membrane Science 323, no. 1 (2008): 60-66.
  14. Giglia, Sal, and David Yavorsky. "Scaling from discs to pleated devices." PDA journal of pharmaceutical science and technology 61, no. 4 (2007): 314-323.
  15. Giglia, Salvatore, Benjamin Bikson, Jerry E. Perrin, and Alfred A. Donatelli. "Mathematical and experimental analysis of gas separation by hollow fiber membranes." Industrial & Engineering Chemistry Research 30, no. 6 (1991): 1239-1248.

Patents

  1. Giglia, Salvatore, David Nhiem, and Gabriel Tkacik. "Enhanced Aerosol Test For Assessing Filter Integrity." U.S. Patent 10,151,679, issued December 11, 2018
  2. Hao, Jibin, Salvatore Giglia, Michael Joens, and Ronald Tuccelli. "Accelerated mixed gas integrity testing of porous materials." U.S. Patent 9,108,138, issued August 18, 2015.
  3. Giglia, Sal, Mani Krishnan, and Nitin Satav. "Method for reducing performance variability of multi-layer filters." U.S. Patent 8,733,556, issued May 27, 2014.
  4. Giglia, Sal, Kevin Rautio, and Mark Blanchard. "Method for improved scaling of filters." U.S. Patent 8,387,256, issued March 5, 2013.
  5. Giglia, Sal, Kevin Rautio, and Mark Blanchard. "Method for improved scaling of filters." U.S. Patent 8,904,641, issued December 9, 2014.
  6. Lewnard, John J., Salvatore Giglia, and Mani Krishnan. "Methods and systems for integrity testing of porous materials." U.S. Patent 7,594,425, issued September 29, 2009.
  7. Bikson, Benjamin, Scott Andrew Bartholomew, Salvatore Giglia, and Bradley Quinn Johnson. "Hollow fiber membrane gas separation cartridge and gas purification assembly." U.S. Patent 6,755,894, issued June 29, 2004.
  8. Bikson, Benjamin, Scott Andrew Bartholomew, Salvatore Giglia, and Bradley Quinn Johnson. "Hollow fiber membrane gas separation cartridge and gas purification assembly." U.S. Patent 6,814,780, issued November 9, 2004.
  9. Bikson, Benjamin, Scott Andrew Bartholomew, Salvatore Giglia, and Bradley Quinn Johnson. "Integral hollow fiber membrane gas dryer and filtration device." U.S. Patent 6,776,820, issued August 17, 2004.
  10. Giglia, Salvatore, Bradley Quinn Johnson, and Benjamin Bikson. "Hollow fiber membrane system assembly with an internal reflux system." U.S. Patent 6,740,140, issued May 25, 2004.
  11. Macheras, James and Sal Giglia “High temperature membrane module tubesheet composed of thermoset resin blends.” U.S. Patent 6,709,494 issued March 23, 2004
  12. Bikson, Benjamin, Salvatore Giglia, Patrick Samuel Nicolas Jr, and Cheryl Ann Ford. "Process of making a structure enhancing hollow fiber module." U.S. Patent 5,897,729, issued April 27, 1999.
  13. Giglia, Salvatore, and Benjamin Bikson. "Hollow fiber membrane separation apparatus." U.S. Patent 5,837,033, issued November 17, 1998.
  14. Bikson, Benjamin, Salvatore Giglia, Patrick Samuel Nicholas Jr, and Cheryl Ann Ford. "Structure enhancing hollow fiber module." U.S. Patent 5,702,601, issued December 30, 1997.
  15. Nicolas Jr, Patrick S., Benjamin Bikson, Salvatore Giglia, and David R. Thompson. "Fluid separation assembly having an purge control valve." U.S. Patent 5,411,662, issued May 2, 1995.
  16. Schulte, Thomas R., Carl J. Heim, Vladimir T. Gorjaczkowski, and Salvatore Giglia. "Pressurizing with and recovering helium." U.S. Patent 5,344,480, issued September 6, 1994.
  17. Schulte, Thomas R., Carl J. Heim, Vladimir T. Gorjaczkowski, and Salvatore Giglia. "Pressurizing with and recovering helium." U.S. Patent 5,390,533, issued February 21, 1995.
  18. Bikson, Benjamin, and Salvatore Giglia. "Double ended hollow fiber bundle and fluids separation apparatus." U.S. Patent 5,160,042, issued November 3, 1992.
  19. Coplan, Myron J., R. Douglas Burchesky, and Salvatore Giglia. "Method for modifying asymmetric membranes by endo-treating." U.S. Patent RE34,155, issued October 27, 1992.
  20. Bikson, Benjamin, and Salvatore Giglia. "Multiple bundle fluid separation apparatus." U.S. Patent 5,071,552, issued December 10, 1991.
  21. Bikson, Benjamin, Salvatore Giglia, and Joyce K. Nelson. "Process for dehydration of gases and composite permeable membranes therefor." U.S. Patent 5,067,971, issued November 26, 1991.
  22. Bikson, Benjamin, and Salvatore Giglia. "Fluid separation device." U.S. Patent 5,026,479, issued June 25, 1991.
  23. Bikson, Benjamin, and Salvatore Giglia. "Method for gas separation using helically wound hollow fibers permeable membrane cartridge." U.S. Patent 4,881,955, issued November 21, 1989.
  24. Bikson, Benjamin, and Salvatore Giglia. "Treatment of permeable membranes." U.S. Patent 4,877,421, issued October 31, 1989.
  25. Coplan, Myron J., and Salvatore Giglia. "Method of manufacturing a hollow filament separatory module with constricted bundle end." U.S. Patent 4,812,184, issued March 14, 1989.
  26. Bikson, Benjamin, and Salvatore Giglia. "Tubesheet for semipermeable membrane devices." U.S. Patent 4,800,019, issued January 24, 1989.
  27. Bikson, Benjamin, Salvatore Giglia, and Gregory Kharas. "Composite separation membranes and the preparation and use thereof." U.S. Patent 4,767,422, issued August 30, 1988.
  28. Coplan, Myron J., R. Douglas Burchesky, and Salvatore Giglia. "Method for modifying asymmetric membranes by endo-treating." U.S. Patent 4,784,880, issued November 15, 1988.

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