Timo Heinrich

Drug research is challenging, demanding but also rewarding. Discovering new medications for areas of unmet medical need like oncology is highly motivating for me.


Perspective

Drug  research is challenging, demanding but also rewarding. Discovering new medications for areas of unmet medical need like oncology is highly motivating for me. The awareness that the own daily work might be contributing to the well-being of patients makes me going the extra mile, especially after loosing relatives because of cancer. Studying current literature and input from conferences but mainly discussions with colleagues makes me push the often cumbersome tasks in drug research foreword. The multi-parameter optimization of initial hits into leads and final development candidates requires the close interaction of experts from many different special sciences and our curiosity to learn in a collaborative fashion from each other is key to success. My contributions to overcome the many hurdles identified on the hit to candidate journey are the intermediate successes that are the salt in the soup of the daily work-live. Our company allows for a great alignment of work- and private-live as basis for excellence.

The multi-parameter optimization of initial hits into leads and final development candidates requires the close interaction of experts from many different special sciences and our curiosity to learn in a collaborative fashion from each other is key to success.

Timo Heinrich

Head of Laboratory

Profile

Joined Merck KGaA, Darmstadt, Germany: 2001

Key research fields and topics:

  • Medicinal Chemistry
  • Oncology
  • Asymmetric synthesis

References

Publications

  1. Heinrich, Timo; Seenisamy, Jeyaprakashnarayanan; Blume, Beatrix; Bomke, Jörg; Eckert, Uwe; Friese-Hamim, Manja; Leuthner, Birgitta; Musil, Djordje; Rohdich, Felix; Zenke, Frank. Identification of MetAP-2 inhibitor clinical compound M8891, J. Med. Chem. In preparation
  2. Heinrich, Timo; Seenisamy, Jeyaprakashnarayanan; Blume, Beatrix; Bomke, Jörg; Calderini, Michel;Eckert, Uwe; Friese-Hamim, Manja; Lehmann, Martin; Leuthner, Birgitta; Musil, Djordje; Rohdich, Felix;Zenke,Frank. Discovery and structure-based optimization of next generation reversible MetAP2 inhibitorsJ. Med. Chem. submitted
  3. Heinrich Timo; Buchstaller Hans-Peter; Bomke Jorg; Krier Mireille; Musil Djordje; Leuthner Birgitta;Cezanne Bertram; Rohdich Felix; Friese-Hamim Manja; Knochel Thorsten; Musil, Djordje; Leuthner,Birgitta; Zenke, Frank. Novel reversible methionine aminopeptidase-2 (MetAP-2) inhibitors based on purine and related bicyclictemplates. BMCL 2017, 27, 551-556
  4. Wucherer-Plietker, Margarita; Merkul, Eugen; Mueller, Thomas J. J.; Esdar, Christina; Knoechel,Thorsten; Heinrich, Timo; Buchstaller, Hans-Peter; Greiner, Hartmut; Dorsch, Dieter; Finsinger,Dirk; Calderini, Michel; Bruge, David; Graedler, Ulrich. Discovery of novel 7-azaindoles as PDK1 inhibitors. BMCL, 2016, 26, 3073-3080
  5. Toulot, Stephanie; Heinrich, Timo; Leroux, Frederic R. Convenient and Reliable Routes Towards 2-Aminothiazoles: Palladium-Catalyzed versus Copper-Catalyzed Aminations of Halothiazoles. Adv. Synth. Catal. 2013, 355, 3263-3272
  6. Gradler, Ulrich; Bomke, Jörg; Musil, Djordje; Dresing, Verena; Lehmann, Martin; Holzemann, Gunter;Greiner, Hartmut; Esdar, Christina; Krier, Mireille; Heinrich, Timo. Fragment-based discovery of focal adhesion kinase inhibitors. BMCL 2013, 23, 5401-5409
  7. Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Lourdusamy Emmanuvel, Santosh Kulkarni, JörgBomke, Felix Rohdich, Hartmut Greiner,Christina Esdar, Mireille Krier, Ulrich Grädler, Djordje Musil. Fragment-based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors. J. Med. Chem. 2013, 56, 1160-1170
  8. Hannes Koolman, Djordje Musil, Timo Heinrich, Mireille Krier, Michael Reggelin. Co-crystal Structures of FAK with a Novel Pyrrolo[2,3-d]thiazole. Acta Cryst. F submitted
  9. Koolman, Hannes; Heinrich, Timo; Reggelin, Michael. Novel syntheses of variably substituted pyrrolo[2,3-d]thiazoles. Synthesis 2010, 18, 3152-3162.
  10. Heinrich, Timo Molecular Targeting in Oncology. Edited by H. L. Kaufman, S. Wadler and K. AntmanChemMedChem 2009, 4, 1378-1379.
  11. Koolman, Hannes; Heinrich, Timo; Boettcher, Henning; Rautenberg, Wilfried; Reggelin, Michael. Syntheses of novel 2,3-diaryl-substituted 5-cyano-4-azaindoles exhibiting c-Met inhibition activityBioorg. Med. Chem. Lett. 2009, 19, 1879-1882.
  12. Reggelin, Michael; Junker, Bernd; Heinrich, Timo; Slavik, Stefan; Buehle, Philipp. Asymmetric Synthesis of Highly Substituted Azapolycyclic Compounds via 2-Alkenyl Sulfoximines:Potential Scaffolds for Peptide MimeticsJ. Am. Chem. Soc. 2006, 128, 4023-4034.
  13. Heinrich, Timo; Boettcher, Henning; Pruecher, Helmut; Gottschlich, Rudolf; Ackermann, Karl-August; vanAmsterdam, Christoph. 1-(1-Phenethylpiperidin-4-yl)-1-phenylethanols as potent and highly selective 5-HT2A antagonists. ChemMedChem 2006, 1, 245-255.
  14. Heinrich, Timo; Boettcher, Henning; Schiemann, Kai; Hoelzemann, Guenter; Schwarz, Michael;Bartoszyk, Gerd D.; van Amsterdam, Christoph; Greiner, Hartmut E.; Seyfried, Christoph A.Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine andchromenonyl-piperazine structural elements in a single molecular entity. Bioorg. Med. Chem. 2004, 12, 4843-4852.
  15. Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried,Christoph A.; Greiner, Hartmut E.; van Amsterdam, Christoph. Synthesis and Structure-Activity Relationship in a Class of Indolebutylpiperazines as Dual 5-HT1AReceptor Agonists and Serotonin Reuptake Inhibitors. J. Med. Chem. 2004, 47, 4684-4692.
  16. Heinrich, Timo; Boettcher, Henning; Bartoszyk, Gerd D.; Greiner, Hartmut E.; Seyfried, Christoph A.; vanAmsterdam, Christoph. Indolebutylamines as Selective 5-HT1A Agonists. J. Med. Chem. 2004, 47, 4677-4683.
  17. Heinrich, Timo; Boettcher, HenningA new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation ofan o-hydroxylated metabolite of vilazodone. Bioorg. Med. Chem. Lett. 2004, 14, 2681-2684.
  18. Heinrich, Timo; Boettcher, Henning; Bartoszyk, Gerd D.; Schwartz, Harry; Anzali, Soheila; Maerz,Joachim; Greiner, Hartmut E.; Seyfried, Christoph A.Bioisosterism of fluorine and cyano as indole substituents. Theoretical, in vitro and in vivo examination.Chimia 2004, 58, 143-147.
  19. Kumar, Kamal; Michalik, Dirk; Castro, Ivette Garcia; Tillack, Annegret; Zapf, Alexander; Arlt, Michael;Heinrich, Timo; Boettcher, Henning; Beller, MatthiasBiologically active compounds through catalysis:Efficient synthesis of N-(heteroarylcarbonyl)-N'-(arylalkyl)piperazinesChemistry 2004, 10, 746-757.
  20. Michalik, Dirk; Kumar, Kamal; Zapf, Alexander; Tillack, Annegret; Arlt, Michael; Heinrich, Timo; Beller,Matthias.A short and efficient synthesis of N-aryl- and N-heteroaryl-N'-(arylalkyl)piperazines.Tet. Lett. 2004, 45, 2057-2061.
  21. Kumar, Kamal; Zapf, Alexander; Michalik, Dirk; Tillack, Annegret; Heinrich, Timo; Boettcher, Henning;Arlt, Michael; Beller, Matthias. Palladium-Catalyzed Carbonylation of Haloindoles: No Need for Protecting Groups.Org. Lett. 2004, 6, 7-10.
  22. Weber, Dirk; Berger, Claudia; Heinrich, Timo; Eickelmann, Peter; Antel, Jochen; Kessler, Horst.Systematic optimization of a lead-structure identities for a selective short peptide agonist for the humanorphan receptor BRS-3.J. Pept. Science 2002, 8, 461-475.
  23. Junker, Bernd; Reggelin, Michael; Heinrich, Timo. Asymmetric Synthesis of Highly Substituted Azapolycyclic Compounds221st ACS National Meeting, San Diego, CA, United States, April 1-5, (2001)
  24. Heinrich, Timo Chemielaboranten – vom Aussterben bedroht?Nachrichten Chemie 2001, 49, 593
  25. Heinrich, Timo; Reggelin, Michael; Bats, Jan W. (+)-(2R,3S,4S,5S,RS)-4-Hydroxy-2-{N-[(R)-1-hydroxy-3-methylbut-2-yl]-4-methylphenylsulfonimidoylmethyl}-3-methyl-1-azabicyclo[3.3.0]octane at 153 K.Acta Cryst. C 1999, C55(11), ii, IUC9900131.
  26. Bats, Jan W.; Heinrich, Timo; Reggelin, Michael.(2S,3R,4R,5R)-2-Benzyl-N-(tert-butoxycarbonyl)-3-hydroxy-4,5-dimethylpyrrolidine at 133 K. Acta Cryst. C 1998, C54(7), ii, IUC9800033.
  27. Bats, Jan W.; Heinrich, Timo; Reggelin, Michael(2S,3R,5S)-2-Benzyl-N-(tert-butoxycarbonyl)-3-hydroxy-5-methylpyrrolidine at 158 K. Acta Cryst. C 1998, C54(8), ii, IUC9800039.
  28. Bats, Jan W.; Heinrich, Timo; Reggelin, Michael.(2S,3S,5R)-2-Benzyl-N-(tert-butoxycarbonyl)-3-hydroxy-5-methylpyrrolidine at 158 K. Acta Cryst. C 1998, C54(8), ii, IUC9800038.
  29. Bats, Jan W.; Heinrich, Timo; Reggelin, Michael. (+)-(2S,3S,4S,5S)-3-[3,5-Bis(trifluoromethyl)benzyloxy]-N-(tert-butoxycarbonyl)-4,5-dimethyl-2-phenylpyrrolidine, (I), and (+)-(2S,3S,4S,5S)-3-[3,5-bis(trifluoromethyl)benzyloxy]-4,5-dimethyl-2-phenylpyrrolidinium p-toluenesulfonate, (II), at 134 K. Acta Cryst. C 1999, C55(10), iv/4-iv/8, IUC9900121/1-2.
  30. Bats, Jan W.; Heinrich, Timo; Reggelin, Michael. (-)-(2S,3S,4S,5R,RS)-1-tert-Butoxycarbonyl-3-hydroxy-5-(1(S)-{N-[(R)-1-hydroxy-3-methylbut-2-yl]-4-methylphenylsulfonimidoyl}ethyl)-4-methyl-2-phenylpyrrolidine at 133 K. Acta Cryst. C 1999, C55(10), iv, IUC9900114.
  31. Reggelin, Michael; Heinrich, Timo. Metalated 2-Alkenylsulfoximides in asymmetric synthesis: diastereoselective preparation of highlysubstituted pyrrolidine derivatives.Angew. Chem. Int. Ed. 1998, 37, 2883-2886.
  32. Reggelin, Michael; Weinberger, Heinz; Heinrich, Timo. Metalated 2-alkenyl sulfoximines in asymmetric synthesis. Regio- and stereoselective synthesis of highlysubstituted tetrahydrofurans. Liebigs Ann. 1997, 9, 1881-1886.

Patents

  1. Heinrich, Timo; Pehl, Ulrich, Perparation of pyrimidine derivatives for use in the treatment of cancer, WO2016128140
  2. Heinrich, Timo; Zenke, Frank; Rohdich, Felix; Friese-Hamim, Manja; Hahn, Diane, Pyrrolidinone derivatives as MetAP-2 inhibitors, WO2016020031
  3. Heinrich, Timo; Zenke, Frank; Krier, Mireille; Friese-Hamim, Manja; Seenisamy,Jeyaprakashnarayanan, Cyclic amides as MetAP-2 inhibitors and their preparation, WO 2013149704
  4. Heinrich, Timo; Rohdich, Felix; Esdar, Christina; Krier, Mireille; Greiner, Hartmut, Preparation of bicyclic heteroaromatic compounds as kinase inhibitors, WO 2013026516
  5. Heinrich, Timo; Brugger, Nadia; Josephson, Kristopher, Substituted azaheterocycles as FAK inhibitors useful in the treatment of cancer and their preparation, WO 2013004332
  6. Heinrich, Timo; Wucherer-Plietker, Margarita; Buchstaller, Hans-Peter, Preparation of 7-azaindole derivatives as PDK1 inhibitors useful in the treatment of tumors, WO 2012175168
  7. Buchstaller, Hans-Peter; Wucherer-Plietker, Margarita; Heinrich, Timo, Heteroaryl-substituted pyrrolo[2,3-b]pyridine derivatives as PDK1 inhibitors and theirpreparation and use in the treatment of tumors, WO 2012072200
  8. Heinrich, Timo; Wucherer-Plietker, Margarita; Buchstaller, Hans- Peter, 1H-Pyrrolo[2,3-b]pyridine derivatives as PDK1 inhibitors and their preparation and use in the treatment of tumors, WO 2012059172
  9. Heinrich, Timo; Zenke, Frank; Calderini, Michel; Musil, Djordje, Pyrrolidinones as MetAP-2 inhibitors and their preparation and use in the treatment oftumors., O 2012048775
  10. Heinrich, Timo; Esdar, Christina; Greiner, Hartmut, Pyrimidine derivatives as FAK inhibitors and their preparation and use in the treatment oftumors, WO 2012022408
  11. Heinrich, Timo; Koolman, Hannes, Thiazole derivatives as kinase inhibitors and their preparation and use in the treatment oftumors, WO 2011072779
  12. Heinrich, Timo; Zenke, Frank; Krier, Mireille; Schiemann, Kai, Preparation of triazaindolizines as MetAP-2 inhibitors, WO 2010083870
  13. Heinrich, Timo; Koolman, Hannes, Preparation of azaindoles as anti-tumor agents, WO 2010046013
  14. Heinrich, Timo; Krier, Mireille; Knoechel, Thorsten; Jonczyk, Alfred; Zenke, Frank; Enderle, Holger, Preparation of pyrrolidines as metap-2 inhibitors, WO 2010003475
  15. Stieber, Frank; Heinrich, Timo; Wienke, Dirk, Preparation of thiazolylpiperidines as sphingosine kinase inhibitors for regulation ofcellular proliferation, WO 2009156041
  16. Heinrich, Timo; Katzer, Michael, Pyrrolopyridine derivatives as 5-HT and 5-HT1A reuptake inhibitors useful in the treatmentof central nervous system disorders and preparation and pharmaceutical compositionsthereof., WO 2009112139
  17. Heinrich, Timo; Staehle, Wolfgang; Greiner, Hartmut; Blaukat, Andree, Novel cyclobutyl compounds as kinase inhibitors for cancer treatment. DE 102006016426
  18. Heinrich, Timo; Blaukat, Andree; Staehle, Wolfgang; Greiner, Hartmut; Kordowicz, Maria, Novel aza heterocycles serving as kinase inhibitors. WO 2006114180
  19. Heinrich, Timo; Blaukat, Andree; Kordowicz, Maria, Preparation of 1H-indol-7-yl pyrimidin-2 -ylamino methanone derivatives and relatedcompounds as IGF-R1 inhibitors for treating cancer., WO 2006108487
  20. Staehle, Wolfgang; Heinrich, Timo; Kordowicz, Maria; Blaukat, Andree; Burgdorf, Lars, Thore, Preparation of pyrrolo[3,2,1-ij]quinolines as tyrosine kinase and Raf kinase inhibitors, WO 2006094600
  21. Heinrich, Timo; Boettcher, Henning; Leibrock, Joachim. Preparation of 7-(4-piperidinylmethyl)indoles as potent 5-HT2A antagonists., WO 2005082886
  22. Heinrich, Timo; Boettcher, Henning; Schiemann, Kai; Hoelzemann, Guenter; Van Amsterdam,Christoph; Bartoszyk, Gerd; Leibrock, Joachim; Seyfried, Christoph. Preparation of indolylbutylpiperazinylbenzofurancarboxamides as serotonin receptorligands and/or serotonin reuptake inhibitors., WO 2004113326
  23. Heinrich, Timo; Boettcher, Henning; Schiemann, Kai; Hoelzemann, Guenter; Van Amsterdam,Christoph; Bartoszyk, Gerd; Leibrock, Joachim; Seyfried, Christoph Preparation of indolylbutylpiperazinylbenzofurancarboxamides as serotonin reuptakeinhibitors and/or serotonin receptor ligands.WO 2004113325
  24. Heinrich, Timo; Pahl, Axel; Luitjens, Bernd-Martin; Finner, Emil; Verveer, Pieter C.; Zorgdrager,Jan. Polymorphic forms of 4-(4-trans-Hydroxycyclohexyl)amino-2-phenyl-7H-pyrrolo[2,3'-d]pyrimidine hydrogen mesylate. WO 2004094428
  25. Hoelzemann, Guenter; Schiemann, Kai; Boettcher, Henning; Heinrich, Timo; Seyfried, Christoph;Leibrock, Joachim; Van Amsterdam, Christoph; Bartoszyk, Gerd, Preparation of benzofuranyloxyalkylaminoalkylindoles as serotonin agonists and reuptakeinhibitors, DE 10306941
  26. Hoelzemann, Guenter; Boettcher, Henning; Schiemann, Kai; Heinrich, Timo; Leibrock, Joachim;Van Amsterdam, Christoph; Bartoszyk, Gerd; Seyfried, Christoph, Preparation of indolyl benzofuran derivatives as 5-HT1A agonists and serotonin reuptakeinhibitors, DE 10305739
  27. Heinrich, Timo; Boettcher, Henning; Schiemann, Kai; Hoelzemann, Guenter; Van Amsterdam,Christoph; Bartoszyk, Gerd; Greiner, Hartmut; Seyfried, Christoph; Brunet, Michel; Zeiller, Jean;Berthelon, Jean, Preparation of substituted benzodioxepins with serotonin reuptake inhibiting activity., WO 2004058746
  28. Heinrich, Timo; Boettcher, Henning; Schiemann, Kai; Hoelzemann, Guenter; van Amsterdam,Christoph; Bartoszyk, Gerd; Leibrock, Joachim; Seyfried, Christoph, Preparation of piperazinylethylindolecarbonitriles as serotonin reuptake inhibitors and 5-HT1A/5-HT1B receptor ligands, DE 10259244
  29. Hoelzemann, Guenter; Crassier, Helene; Boettcher, Henning; Heinrich, Timo; Schiemann, Kai;Leibrock, Joachim; Van Amsterdam, Christoph; Bartoszyk, Gerd; Seyfried, Christoph, Preparation of indole derivatives as 5HT receptor antagonists., WO 2004052886
  30. Hoelzemann, Guenter; Schiemann, Kai; Heinrich, Timo; Boettcher, Henning; Leibrock, Joachim;Van Amsterdam, Christoph; Bartoszyk, Gerd; Seyfried, Christoph, Preparation of pyridinylmethylaminobutylindolecarbonitriles as serotonin 5-HT1A and 5-HT1D receptor ligands, DE 10254596
  31. Schiemann, Kai; Boettcher, Henning; Heinrich, Timo; Hoelzemann, Guenter; Van Amsterdam,Christoph; Bartoszyk, Gerd; Leibrock, Joachim; Seyfried, Christoph, Preparation of piperazinylalkylindoles as 5-HT1A and/or 5-HT1D agonists and as 5-HTreuptake inhibitors., WO 2004041815
  32. Weber, Dirk; Kessler, Horst; Berger, Claudia; Antel, Jochen; Heinrich, Timo, Synthesis and bioactivity of peptidomimetics as agonists for bombesin receptor subtype 3, WO 2003104196
  33. Schadt, Oliver; Boettcher, Henning; Leibrock, Joachim; Schiemann, Kai; Heinrich, Timo;Hoelzemann, Guenter; Van Amsterdam, Christoph; Bartoszyk, Gerd; Seyfried, Christoph, Preparation of indole-3-carbonitriles as excitatory amino acid antagonists for the treatmentof neurodegenerative diseases., WO 2003087086
  34. Reggelin, Michael; Heinrich, Timo; Junker, Bernd; Antel, Jochen; Preuschoff, Ulf, Method for stereochemically controlled preparation of isomerically pure highly substitutedazacycloalkanamines and -ols., WO 9958500Ta

Comprehensive Conference List

  • 1997: Heidelberg Symposium: Research of Georg Wittig – Relevance to Chemistry Today
  • 1998: Heidelberg Symposium: The Impact of Organic Synthesis on Drug Discovery
  • 1999: 3rd Winter Conference Medicinal and Bioorganic Chemsitry, Steamboat Springs, CO, US
  • 1999 GDCh (Prof. Wiese): Einführung in die Medizinische Chemie: Biol. & chem. Grundlagen der Wirkstoffentwicklun
  • 1999 GDCh (Prof. Blechert): Moderne Reaktionen in der organischen Chemie
  • 2000: 1st Florida Heterocyclic Conference and Pre-Conference Short Course on Heterocyclic Chemistry
  • 2001: 4th Winter Conference Medicinal and Bioorganic Chemsitry, Steamboat Springs, CO, USAAmerican Chemical Society (ACS), San Diego
  • 2002 Conference on Stereochemistry, Bürgenstock, Switzerland
  • 2003 ‘Molecular Recognition’, Louvin-la-Neuve, BelgiumNSBC, Hamburg
  • 2003 Fluorine in the Life Sciences, Bürgenstock, Switzerland
  • 2004 Gordon Research Conference: Molecular Therapeutics of Cancer, Colby-Sawyer-College, New London, NH, USA
  • European Federation Medicinal Chemistry (EFMC), CopenhagenNSBC, Hamburg
  • 2005 Gordon Research Conference: Medicinal Chemistry, Colby-Sawyer-College, New London, NH, USA
  • 2nd Anglo-Swedish Medicinal Chemistry Symposium, Åre, Sweden
  • HtI, WermelskirchenNSBC, Aachen
  • 2006 NSBC, Berlin2007 American Association for Cancer Research (AACR), Los Angeles
  • 3rd Anglo-Swedish Medicinal Chemistry Symposium, Åre, Sweden
  • HtI, BerlinNSBC, Dortmund
  • 2008 European Organisation for Research and Treatment of Cancer (EORTC), Geneva
  • EFMC, ViennaNSBC, Konstanz
  • 2009 Frontiers in Medicinal Chemistry, Heidelberg
  • Trends in Drug Research, Noordwijkerhout, the Netherlands
  • NSBC, Hannover
  • 2010 EORTC, BerlinACS, Boston
  • 2011 5th Anglo-Swedish Medicinal Chemistry Symposium, Åre, Sweden
  • NSBC, Karlsruhe
  • 2012 EFMC, Berlin
  • 2013 RICT Nice
  • 2014 EFMC Lisboa
  • Cambridge (Kinase 2014: Past, Present & Beyond)
  • 2015 RICT Avignon
  • HtI Basel
  • 2016 BOSS Antwerpen
  • 6th RSC / SCI symposium on GPCRs in Medicinal Chemistry, Verona
  • 2017 RICT ToulouseGordon Research Conference on GPCR, Barga
  • 2018 BOSS Brussels

Poster

  • BOSS, Brussels 2018, Timo Heinrich, Hans-Peter Buchstaller, Bertram Cezanne, Felix Rohdich, Jörg Bomke, Manja Friese-Hamim, Mireille Krier, Thorsten Knöchel, Djordje Musil, Birgitta Leuthner, Frank Zenke, Uwe Eckert, Michael Katzer, MetAP-2 inhibitors in Oncology; Reversible ligands based on Purine and related scaffolds
  • Gordon Research Conference on GPCR 2017, Timo Heinrich, GPCR for Oncology
  • RICT, Avignon 2015, Timo Heinrich, Hans-Peter Buchsteller, Ulrich Grädler, Hartmut Greiner, Christina Esdar, Meriolin Derived Highly Potent PDK1 Inhibitors
  • EFMC, Lisboa 2014, Timo Heinrich, Hartmut Greiner, Thorsten Knöchel, Mireille Krier, Jörg BomkeNew Reversible MetAP-2 Inhibitors
  • EFMC, Berlin 2012, Timo Heinrich, Nadia Brugger, Felix Rohdich, Christina Esdar, Hartmut Greiner, Mireille Krier,Jeyaprakashnarayanan Seenisamy, Jayashankaran Jayadevan, Venkat raman SundararamanNew Highly Selective FAK Inhibitors
  • 5th Anglo-Swedish Medicinal Chemistry Symposium, Åre: 2011, Timo Heinrich, Ulrich Grädler, Henning Böttcher, Andree Blaukat, Adam Shutes, (5-CN-1H-Indol-3-yl)-Butyl-Amines as Allosteric IGF-1R Inhibitors
  • Gordon Research Conference – Medicinal Chemistry 2005, New London, USA, Timo Heinrich, Henning Böttcher, Hartmut E. Greiner and Christoph A. SeyfriedHighly Potent and Selective 5-HT1A Agonists as Possible PET Ligands
  • Bürgenstock 2003: Fluorine in the Life Sciences, T. Heinrich, H. Böttcher, J. März, S. Anzali, H. E. Greiner and C. A. Seyfried, Variations at an Important Pharmacophore, Bioisosterism at the Indole: F and CN are Exchangeable
  • Heidelberg Symposium 1997, M. Reggelin, T. Heinrich, “Metallated 2-Alkenylsulfoximines in the Asymmetric Synthesis of Highly Substituted Aza-Heterocycles”

Talks

  1. Discovery of New FAK inhibitors (invitation for August 29/30), FinMedChem 2013
  2. Novel Substituted Indoles as Highly Selective 5-HT2A Antagonists, EFMC, Copenhagen 2004
  3. Nachwuchswissenschaftler-Symposium Bioorganische Chemie (NSBC)
    • Variations at an Important Pharmacophore, Bioisosterism at the Indole: F and CN areExchangeable, Hamburg 2003
    • Novel Substituted Indoles as Highly Selective 5-HT2A Antagonists, Hamburg 2004
    • Highly Potent and Selective 5-HT1A Agonists as Possible PET Ligands, Aachen 2005
    • Privileged-Structure Approach’ in Oncology Research, Berlin 2006
    • Allosteric Kinase Inhibitors, Dortmund 2007
  4. Hochschule-trifft-Industrie (HtI)
    • Highly Potent and Selective Dual 5-HT1A Agonists and SSRIs as Potential Antidepressants, Wermelskirchen 2005
    • Allosteric Kinase Inhibitors, Berlin 2007
    • MetAP-2 inhibitors based on Purin and related scaffolds, Scharzwald 2017

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