Future Insight Prize 2023 Awarded to Khalid Salaita for Early Detection of Pandemics

We have awarded Khalid Salaita, Emory University, Atlanta, U.S.A., with the Future Insight Prize 2023 for research on a pandemic early alert system.

11 Jul 2023 | Darmstadt, Germany
  • Khalid Salaita awarded a research grant for the development of sensors to detect pathogens automated by DNA motors
  • DNA motors already proven to detect SARS-CoV-2

Merck KGaA, Darmstadt, Germany, today awarded Khalid Salaita, Samuel Candler Dobbs Professor in the Department of Chemistry at Emory University, Atlanta, Georgia, U.S.A., with the Future Insight Prize 2023 worth € 500,000 for research on a pandemic early alert system. Salaita’s group is developing a novel platform technology for automated surveillance and tracing of airborne pathogens in real time.

“The importance of being prepared has been a key lesson from the Covid-19 pandemic. There are many promising collaborations to build an inclusive global framework for pandemic preparedness, but we still lack an effective early warning system to detect potential threats before it is too late,” Belén Garijo, Chair of the Executive Board and CEO of Merck KGaA, Darmstadt, Germany, said. “The pioneering work of Khalid Salaita could help fill this urgent gap in our global defenses. We are confident that the Future Insight Prize 2023 will help to accelerate his efforts to develop this highly promising technology.”

“I am extremely grateful for being awarded the Future Insight Prize 2023 as this enables us to continue our path towards an early warning system for emerging threats,” Khalid Salaita said in Darmstadt on Tuesday. “Our research sets the stage for using DNA motors that allow fully automated detection of pathogens without human intervention or sample processing. Importantly, the signal can be transduced using a cell phone.”

Salaita’s research group has developed a DNA rolling system as the technological centerpiece of the proposed pandemic early alert system. The moving DNA particles are propelled by enzymatic consumption of an RNA fuel source. The DNA motors developed in Salaita’s laboratory can carry many copies of DNA cargo with velocities of up to 100 nm/min. Such motors hold promise in biosensing, molecular computing, creating synthetic cells and now to systematically test structure-function relationships at the nanoscale.

The Atlanta-based researchers went one step further and tested the idea with SARS-CoV-2. Using DNA motors they developed a mechanical-based viral sensing platform called Rolosense which is advantageous, as it reduces cost and simplifies the instrumentation needed for readout. In this research they were able to detect SARS-CoV-2. The signal was transduced using a cell phone in real time and with GPS coordinates. Next steps for Salaita’s research group on the currently very early-stage system will include the screening and identification of high-affinity and high-specificity virus binding ligands. They will be tested against a panel of pathogens. Microfluidic chips for airborne droplet capture will also be tested and implemented.

Salaita (44) started research on the topics he was recognized for today as an Assistant Professor of Chemistry at Emory University in 2009. He did his PhD thesis from 2001 to 2006 at Northwestern University, Evanston, Illinois, U.S.A., and worked as a Postdoctoral Fellow from 2006 to 2009 in the Department of Chemistry at the University of California, Berkeley, California, U.S.A.

The Future Insight Prize puts forth a vision for ambitious dream products and is intended to trigger curiosity and creativity worldwide on how to make this vision a reality. The winner of the Future Insight Prize is selected by a jury comprising more than 80 renowned top scientists from different research fields – including many Nobel laureates. Merck KGaA, Darmstadt, Germany first announced the prize in 2018. It is planned to award the Future Insight Prize 2024 on research in fighting future pandemics with artificial intelligence.

Previous Future Insight Prize winners

Name

Topic

Year

Institute

Prof Tobias Erb

CO2 conversion

2022

Max Planck Institute for Terrestrial Microbiology in Marburg, Germany

Prof. Ting Lu

Food generation

2021

University of Illinois Urbana-Champaign, USA

Prof. Stephen Techtmann

Food generation

2021

Michigan Technological University, USA

Prof. Stefan Sieber

Multi-drug resistance

2020

Technical University of Munich, Germany

Prof. James Crowe

Pandemic protection

2019

Vanderbilt University Medical Center, Nashville, Tennessee, USA Scripps Research Institute, La Jolla, USA

Prof. Pardis Sabeti

Pandemic protection

2019

Harvard University and the Broad Institute, Cambridge, Massachusetts, USA Yale University, New Haven, USA

Merck KGaA, Darmstadt, Germany will present the Johann Anton Merck Award tomorrow, July 12, 2023. You can follow live here on our website. With this € 30,000 award, first handed over in 2020 to Prof. Caroline Dive (58) of the Cancer Research UK Manchester Institute, Manchester, United Kingdom, we honor outstanding scientific pre-clinical research in the areas of our Healthcare business sectors‘s strategic focus.

 

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About Merck KGaA, Darmstadt, Germany

Merck KGaA, Darmstadt, Germany, a leading science and technology company, operates across life science, healthcare and electronics. More than 64,000 employees work to make a positive difference to millions of people’s lives every day by creating more joyful and sustainable ways to live. From providing products and services that accelerate drug development and manufacturing as well as discovering unique ways to treat the most challenging diseases to enabling the intelligence of devices – the company is everywhere. In 2022, Merck KGaA, Darmstadt, Germany, generated sales of € 22.2 billion in 66 countries.

The company holds the global rights to the name and trademark “Merck” internationally. The only exceptions are the United States and Canada, where the business sectors of Merck KGaA, Darmstadt, Germany, operate as MilliporeSigma in life science, EMD Serono in healthcare and EMD Electronics in electronics. Since its founding in 1668, scientific exploration and responsible entrepreneurship have been key to the company’s technological and scientific advances. To this day, the founding family remains the majority owner of the publicly listed company.

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