Programme

Monday - 8th November 2021

 
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Workshop 1

Cryo-EM
(facilities, sample preparation, data collection and processing etc.)
Confirmed speakers:

  • Marta Carroni, SciLifeLab, Sweden: "Facilitating accessibility to cryo-EM – The Swedish cryo-EM facility "
  • Andreas Schenck, Novartis, Switzerland: "Streamlining data collection and analysis for cryo-EM based structure determination"
  • Mathieu Botte, leadXpro, Switzerland: "Pro-Macrobodies: A new facilitator for high resolution cryo-EM structure determination"
  • Michael Saur, Astex, UK
15:30 - 16:00 Break 5 Mins
sponsor talks
Videos
16:00 - 17:30 Session 1

AI opportunities in SBDD:
Confirmed speakers:

  • Lewis Mervin AZ, UK and Ola Engkvist, AZ, Sweden: "Privacy preserving machine learning in the pharmaceutical industry"
  • Ilaria Ferlenghi, GSK, UK: “GEMINI: an integrated structure and AI based approach for new vaccine identification”
  • Lovisa Holmberg Schiavone and Aurelie Bornot, AZ, Sweden: "A pre-competitive consortium to share data and build predictive models for recombinant protein expression" including subsequent panel discussion
17:30 - 18:15 Keynote Lecture

Tuesday - 9th November 2021

 
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Workshop 2

Automation and method development in crystallography
Confirmed speakers:

  • Joachim Diez, Expose, Switzerland
  • Irina Cornaciu, ALPX, France
  • Romain Talon, ESRF, France
15:30 - 16:00 Break 5 Mins
sponsor talks
Videos
16:00 - 17:30 Session 2

Integrative Structural Biology
Confirmed speakers:

  • Taiana Maia De Oliveira, AZ, UK: „Cryo-EM and Integrative Structural Biology at AstraZeneca“
  • Dimitry Tegunov, Genentech, US: „Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells“
  • John Briggs, MRC, UK:„In virus structural biology of SARS-CoV-2 and other viruses“
17:30 - 18:15 Virtual EMBL and ESRF Facility Tour

Wednesday - 10th November 2021

 
13:45 - 14:00 Webinar Opens
14:00 - 15:30 Session 3

Structural Biology Data Management in the Big Data Era

Confirmed speakers:

  • Markus Kroemer, Novartis, Switzerland
  • Raphael Bourgeas, EMBL, France and Clemens Vonrhein, Global Phasing Ltd, UK: "Integrated data tracking and analysis along the crystallography experimental workflow"
  • Robbie Joosten, NKI, The Netherlands: „Speeding up the last mile of structure solution with PDB-REDO“
  • Mihaly Varadi, EBI, UK: "PDBe-KB: An integrated knowledge base of molecular structures and their functional annotations that supports large scale data mining"

 

15:30 - 16:00 Break 5 Mins
sponsor talks
Videos
16:00 - 17:30 Session 4

Case studies

Confirmed speakers:

  • Frank von Delft, University of Oxford, UK: "Systematic progression of fragments by linking AI and experiment by robotics"
  • Jan Steyaert, Vrije Universiteit Brussel, Belgium: „From Nanobodies to Megabodies for applications in cryo-EM“
  • Rob van Montfort, ICR, UK: “Achieving in vivo target depletion through the discovery and optimization benzimidazolone BCL6 degraders”
  • Markus G. Rudolph, Roche, Switzerland: “Selective DDR1 over DDR2 inhibitors from efficient screening and structure-guided design”
17:30 - 18:15 Poster session