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Disclaimer
Publication of Merck KGaA, Darmstadt, Germany.
In the United States and Canada the subsidiaries of
Merck KGaA, Darmstadt, Germany operate under the umbrella brand EMD.
The virtual event will be organized in two sessions (9th and 10th November 2020) from 16:00 to 18:00 CET to facilitate participation from colleagues overseas.
Each session will focus on a specific topic and will include two keynote talks followed by a round-table discussion.
Monday 9th November 2020
Ternary PROTAC structures – essential or misleading for drug discovery?
Moderator: Dr. Ingo Hartung, Merck KGaA, Darmstadt, Germany
16:00 - 16:10
Virtual conference opening and introduction
16:10 - 16:40
Dr. Alessio Ciulli (Univeristy of Dundee, UK) - Targeted protein degradation: how PROTACs work and why the ternary complex matters
16:40 – 16:50
Questions
16:50 - 17:20
Dr. Joe Patel (C4 Therapeutics, Watertown, MA) - Computational Methods for Degrader Ternary Complex Prediction Using HDX Data
17:20– 17:30
Questions
17:30 - 18:30
General discussion
Tuesday 10th November 2020
Protein structure prediction using machine learning
Moderator: Dr. Kristin Brown, GSK, Stevenage, UK
16:00 - 16:05
Introduction
16:05 - 16:35
Dr. Mohammed AlQuraishi (Columbia University in New York, NY) - Nearly end-to-end differentiable learning of protein structure
16:35 – 16:45
Questions
16:45 - 17:15
Dr. David Baker (University of Washington, Seattle, WA) - Combatting coronavirus with de novo protein design
