Lisa Keefe is Vice President for Advancing Therapeutics at Hauptman-Woodward Medical Research Institute in Buffalo, New York, and leads the IMCA-CAT team in accelerating drug discovery through synchrotron-based structural biology. The IMCA-CAT facility is located at the Advanced Photon Source, Argonne National Laboratory, in Illinois, and features a state-of-the-art insertion device beamline optimized for high-throughput macromolecular crystallography. For over 20 years, Lisa and her team have worked with researchers at many of the major pharmaceutical companies, including AbbVie, Bristol-Myers Squibb, Janssen, Merck KGaA, Darmstadt, Germany, Novartis, and Pfizer, as well as many smaller biotech companies, impacting the vast majority of their structure-based drug design projects and resulting in the development of numerous drugs now on the market. Lisa was introduced to crystallography while studying chemistry at Vassar College, and upon graduation, continued pursuing her interests in the laboratory of Jenny Glusker at the Institute for Cancer Research, Fox Chase Cancer Center. She then went to The Johns Hopkins University School of Medicine where she earned her PhD in Biophysics and Biophysical Chemistry under the supervision of Eaton E. Lattman. Her career in synchrotron radiation began at the National Synchrotron Light Source during a postdoctoral fellowship jointly with Argonne and Brookhaven National Laboratories.