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Biopharma Mini Library*

Gain free access to our Mini Library of exclusive research & development compounds.


 

* This program is not open to U.S. healthcare providers.

Get access to our compounds for your research

We offer free access to our Mini Library as part of our Open Innovation Initiative! Our Mini Library contains our former Biopharma research and development compounds and their derivatives. We invite you to use these compounds in your assay systems. Even more, you are the owner of the results of the experiments you performed with these compounds! The compounds – predominantly drug-like and not found elsewhere – cover a wide range of molecular targets (see link below), and could potentially interact with and modulate the activity of e.g. an enzyme, receptor or transporter you are evaluating.

The molecular targets comprise enzymes (e.g. kinases, phosphatases, proteases, cyclic nucleotide phosphodiesterases, etc.), hormone or neurotransmitter receptors (serotonin, angiotensin II, endothelin, etc.), transporters, ion channels and several others. All compounds are small organic compounds (no biologicals), which will be supplied in 50 µl in a concentration of 10 mM in a solution in dimethyl sulfoxide (DMSO) on a 96-well microtiter plate. In the first roll-out, the number of plates will be limited to 100.

 A more detailed list of the target classes in the Mini Library and the number of compounds per class is available as a download here (login required). 

Please read the information below to find out how to apply, as well as how to obtain information on the structures of the compounds and their main biological activities. 

Who can apply?

Merck KGaA, Darmstadt, Germany, invites individuals from universities, research institutes and private companies to apply to obtain a copy of our Mini Library.

This program is not open to U.S. healthcare providers.

How does it work?

After signing the mini library agreement, we will send you free of charge the mini library 96-well plate. In exchange for access to our compounds, we ask you to share all data generated in your evaluations with us. However you will obtain the ownership of the results of your experiments. We may then offer a follow-up collaboration or even a licensing or other long term agreement based on your results. Obviously, you may also use the results for a scientific publication. The legal, intellectual property and commercial aspects as well as the rules for a publication are covered in the “Mini Library Agreement” (see also: How to apply). 

Downloads (Login required)  

Your benefits

  • You will receive a unique set of non-commercially available compounds; most have already achieved a specific degree of maturity with regard to their characterization towards their targets, as well as in vitro and in vivo effects. For some compounds, human data is available.
  • The collection contains some former development candidates (including clinical Phase II) for repurposing, including a full toxicological assessment package.
  • You can identify compounds that could be of assistance to you in your research.
  • You may also uncover new applications for these compounds while using them in a fresh experimental setting.
  • You will have access to our experienced researchers to discuss your data, and, dependent on your research, you may have the opportunity to start a joint drug discovery or development program.
  • Our Biopharma Mini Library is provided free of charge.
  • You could be eligible to receive success payments for reaching certain milestones (for details see “Mini Library Agreement”).

How to apply

Please register to find the Mini Library agreement. To apply, submit a short description of the assay(s) in which you wish to test the compounds, as well as the anticipated targets for which you plan to test the compounds. If applicable, please describe the potential
therapeutic use that could be derived from the outcome of your investigations. All data must be provided on a non-confidential basis.

Upon receiving your application, we will inform you of the results of the review process within four weeks. We can accept or decline your application at our own discretion. If questions arise, you might be contacted to clarify open issues in order to allow a proper decision.

If we approve your application, you (and/or your institution) will be asked to sign the “Mini Library Agreement”.

After registration, you will have access to the Mini Library Agreement. Please note that the agreement has been set up and phrased in such a way as to be acceptable to as many partners as possible. We kindly ask you to accept the agreement “as is”, as we cannot re-negotiate conditions on an individual basis.

Further information can be found in the Frequently Asked Questions, as well as in the document How to apply.

Please read both carefully before beginning your application.

FAQs

How can I participate in the Mini Library program?

How can I participate in the Mini Library program?

If you are interested in participating in the program, please fill the registration form to get access to the mini library agreement.

If you have any questions that are not answered on the webpage or in this FAQ document, please feel free to email us at Open_Innovation@emdgroup.com

Can I participate in the Mini Library program as a private individual?

Can I participate in the Mini Library program as a private individual?

If you are legally and practically in the position to conduct the anticipated experiments with the Mini Library, you can participate in the program as an individual. However, if you are an employee, e.g. in an academic institution, then, in many cases, your employer (e.g. the institution) is the legal owner of the experimental data obtained in your laboratory. In such cases, the institution is the legal contract partner. Because this might vary among different institutions or countries, please check with your institution first as to whether you or your institution are the correct partner for the Mini Library Agreement.

If you wish to participate in the program as an individual, we may ask you for proper legal documentation as to the ownership of the experimental data you plan to obtain with the Mini Library compounds. 

Can the Agreement be amended or adapted to my institution’s requirements?

Can the Agreement be amended or adapted to my institution’s requirements?

The agreement has been set up to accommodate the needs of both parties. The Mini Library Agreement covers intellectual property rights and inventor rights, commercial use and financial compensation for both parties. Thus, the agreement should be acceptable for the majority of (academic as well as commercial) institutions and potential partners. 

In which format do I have to provide the application for your evaluation?

In which format do I have to provide the application for your evaluation?

Once you’ve registered on our Open Innovation Portal, you will receive a confirmation email. To apply, you should reply to that confirmation email and include your application as an attachment (e.g. Word doc, PDF, etc.). A brief description of the planned experiments and its objectives is sufficient (e.g. 0.5 -1 page).

What should be the level of detail of the application?

What should be the level of detail of the application?

Your application should be detailed in such a way that the essence of your proposal can be assessed directly by our experts. However, only non-confidential information should be provided for the application. The non confidential nature of your submitted proposal has to be confirmed in writing within your application.

Is my submitted information managed confidentially?

Is my submitted information managed confidentially?

Please provide us with non-confidential information only! Once the mini library agreement is signed, we can establish a legal base to exchange confidential information.

How is the application handled after submission?

How is the application handled after submission?

We will confirm receipt of your proposal via email. Your application will be reviewed by our Open Innovation Governance Committee, depending on the topics there are representatives from all therapeutic areas and from our Technology Platforms, Patent and Legal Departments. In the case of open issues or questions, you may be contacted to clarify these issues and provide additional information. Based upon the decision of the Governance Committee, you will be informed of your application's acceptance or rejection within four weeks.

How do I send my application for the Mini Library to Merck KGaA, Darmstadt, Germany?

How do I send my application for the Mini Library to Merck KGaA, Darmstadt, Germany?

Please submit your application only after you have registered yourself at our Open Innovation Portal. After registering, you will receive a confirmation email from us. Please submit your application as a reply to this email. Submissions made without registration via our Open Innovation Portal will not be accepted. 

How are legal aspects and IP rights handled in regard to my application?

How are legal aspects and IP rights handled in regard to my application?

Please refer to ‘Is my submitted information managed confidentially?’

Who owns the rights to the data obtained in utilizing the Mini Library?

Who owns the rights to the data obtained in utilizing the Mini Library?

You will own the results of your experiments. We are interested to evaluate these results and to potentially offer a follow-up collaboration. We therefore ask you to share the results with us. You find all the details specified in the mini library agreement.

Do I have to pay for the Mini Library?

Do I have to pay for the Mini Library?

If your application is approved by our Open Innovation Governance Committee, you will be provided access to the Mini Library free of charge. Merck will also cover all shipping costs. 

How long can I use the Mini Library for?

How long can I use the Mini Library for?

In accordance with the Mini Library Agreement, you will have a maximum of two years for your experiments, during which time you should send in your data. 

Can I obtain additional material of (a) compound(s) if I am interested in it?

Can I obtain additional material of (a) compound(s) if I am interested in it?

If you are interested in obtaining additional material of (a) specific compound(s), you can submit a request for the compound(s), the necessary amount and a short description of the anticipated use of the compound(s) to: Open_Innovation@emdgroup.com If your application is granted, you will be asked to sign our standard Material Transfer Agreement. 

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