Merck KGaA, Darmstadt, Germany, to Present Data On Comparative Effectiveness of Rebif® versus Oral Therapy at AAN Annual Meeting

Merck KGaA, Darmstadt, Germany, a leading science and technology company, today announced that clinical and real-world data about interferon beta-1a (Rebif®), will be presented at the American Academy …

14 Apr 2016 | Darmstadt, Germany
  • Real-world data of relapse rates in patients with Multiple Sclerosis (MS) newly initiating self-treatment with interferon beta-1a (Rebif®) to be presented

Merck KGaA, Darmstadt, Germany, a leading science and technology company, today announced that clinical and real-world data about interferon beta-1a (Rebif®), will be presented at the American Academy of Neurology’s (AAN) 68th Annual Meeting, taking place April 15-21, 2016, in Vancouver, British Columbia, Canada.

A real-world assessment of relapse rates in patients with MS newly initiating self-injectable treatment with interferon beta-1a versus an oral disease-modifying therapy, as well as the clinical effect of interferon beta-1a on ‘no evident disease activity’ (NEDA) and MRI outcomes, will be revealed in data presented by Merck KGaA, Darmstadt, Germany.

“Patients with MS have more choices than ever before, but, given the potential devastation of this disease, consistent validation and balance of comparative effectiveness is paramount to selecting the most appropriate treatment,” said Rick Munschauer, Vice President, Medical Affairs, Neurology and Immunology, EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, Germany, in the U.S and Canada. “We are committed to enhancing care for people living with MS. That commitment includes continuing to deepen our understanding of the clinical and real-world impact of Rebif to inform the most optimal choice of therapy for patients. With a well-established safety profile supported by more than 20 years of combined clinical trial and patient experience and efficacy across three key disease measures – including reducing relapse rates and delaying disability progression – Rebif is an important treatment option for relapsing MS.”

The following abstracts have been accepted for presentation at the 68th AAN Annual meeting:

 

Title

Lead Author

Abstract/ Poster #

Presentation date/time

Session

Predictive Value of 6- Month T2 and Enhancing Lesions Among Patients with RRMS Receiving Interferon β-1a Subcutaneously Thrice Weekly or Placebo: Post Hoc Analyses of PRISMS Data

D. Li

P1.401

April 16, 2016

5:30 p.m.

Poster Session P1: 8:30 a.m.

to 7:00 p.m.

Age-, Sex-, and Geographic Region- Specific Comorbidity in Patients with Multiple Sclerosis

NC.

Edwards

P2.190

April 17, 2016

4:00 p.m.

Poster Session P2: 8:30 a.m.

to 5:30 p.m.

Magnetic Resonance Imaging (MRI) Outcomes in Patients with Relapsing-Remitting Multiple Sclerosis (RRMS) Treated with     Cladribine Tablets: Results from the 120- Week Phase IIIb Extension of the CLARITY Study

G. Comi

P2.114

April 17, 2016

4:00 p.m.

Poster Session P2: 8:30 a.m.

to 5:30 p.m.

Role of Family Planning in Women of Child- Bearing Age with Multiple Sclerosis (MS) in Switzerland: Results of the Women with MS (WWMS) Patient Survey

S. Muehl

P2.105

April 17, 2016

4:00 p.m.

Poster Session P2: 8:30 a.m.

to 5:30 p.m.

 

Adherence to Subcutaneous IFN-β1a - Final Analysis of the

Non-Interventional Study READOUTsmart Using the Dosing Log and Readout Function of RebiSmart®

P.

Rieckmann

P3.098

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Association of Timing of Disease-Modifying Drug Treatment Initiation on Multiple Sclerosis Relapse Rates in Newly Diagnosed Patients

AL. Phillips

P3.118

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Clinical Efficacy of Cladribine Tablets in Patients with Relapsing- Remitting Multiple Sclerosis (RRMS): Final Results from the 120- Week Phase IIIb Extension Trial to the CLARITY Study

G.

Giovannoni

P3.028

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Effect of Early Versus Delayed Subcutaneous Interferon (scIFN) β-1a to Achieve No Evidence of Disease Activity (NEDA) in Patients with Clinically Isolated Syndrome (CIS): a Post- Hoc Analysis of REFLEXION

P. Coyle

P3.111

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Efficacy of Cladribine Tablets* as Add-On to IFN-Beta Therapy in Patients with Active Relapsing MS: Final Results from the Phase II ONWARD Study

X.

Montalban

P3.029

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Efficacy of Cladribine Tablets* in ORACLE Study Patients who Retrospectively Met 2010 McDonald Multiple Sclerosis (MS) Criteria at Baseline

MS.

Freedman

P3.035

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

 

 

 

 

 

 

Interferon β-1a SC tiw Reduces Mild to Moderate and Moderate to Severe Relapses and Disease Activity over 1 Year in Patients with Relapsing MS: Post Hoc Analyses of PRISMS Data

A. Boster

P3.036

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Natural and Inducible Regulatory T Cell Subsets in a Large Cohort of Relapsing Remitting Multiple Sclerosis Patients Treated with Interferon- Beta and Followed for 24 Months

F. Serana

P3.077

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Safety and Tolerability of Cladribine Tablets* in Patients with Relapsing- Remitting Multiple Sclerosis (RRMS): Final Results from the 120- Week Phase IIIb Extension Trial to the CLARITY Study

S. Cook

P3.095

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

Slowing of Disability Progression Based on 6- Month Confirmed EDSS in Patients with Relapsing-Remitting Multiple Sclerosis (RRMS) Treated with Cladribine Tablets* in the CLARITY Study: a Post-Hoc Subgroup Analysis

S. Cook

P3.058

April 18, 2016

5:30 p.m.

Poster Session P3: 8:30 a.m.

to 7:00 p.m.

MRI Frequency and No Evidence of Disease Activity Status Among Patients with RRMS Receiving IFN β-1a SC tiw or IFN β-1a IM qw: Post Hoc Analyses of EVIDENCE

AT. Reder

P6.190

April 21, 2016

4:00 p.m.

Poster Session P6: 8:30 a.m.

to 5:30 p.m.

 

Predictive Value of Early MRI Measures for Long- Term Disease Activity in Patients with Relapsing– Remitting Multiple Sclerosis Receiving IFN β-1a SC tiw or IFN β-1a IM qw: Post Hoc Analyses of the EVIDENCE Study

PK. Coyle

P6.189

April 21, 2016

4:00 p.m.

Poster Session P6: 8:30 a.m.

to 5:30 p.m.

Real-World Assessment of Relapse Rates in Patients with Multiple Sclerosis Newly Initiating Subcutaneous Interferon β-1a vs Oral Disease- Modifying Drugs

CM. Kozma

P6.178

April 21, 2016

4:00 p.m.

Poster Session P6: 8:30 a.m.

to 5:30 p.m.

*Cladribine tablets is an investigational product and not approved for use in any indication in the United States. RebiSmart®, an electronic device for self-injection of Rebif®, is also not approved in the United States.

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Merck KGaA, Darmstadt, Germany 
Merck KGaA, Darmstadt, Germany, is a leading science and technology company in healthcare, life science and performance materials. Around 50,000 employees work to further develop technologies that improve and enhance life - from biopharmaceutical therapies to treat cancer or multiple sclerosis, cutting-edge systems for scientific research and production, to liquid crystals for smartphones and LCD televisions. In 2015, Merck KGaA, Darmstadt, Germany, generated sales of € 12.85 billion in 66 countries.

 
Founded in 1668, Merck KGaA, Darmstadt, Germany, is the world's oldest pharmaceutical and chemical company. The founding family remains the majority owner of the publicly listed corporate group. Merck KGaA, Darmstadt, Germany, holds the global rights to the „Merck" name and brand. The only exceptions are the United States and Canada, where the company operates as EMD Serono, MilliporeSigma and EMD Performance Materials.

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